WormBase Tree Display for Gene: WBGene00001089
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| WBGene00001089 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | dre-1 | Person_evidence | WBPerson759 | |||||
| Sequence_name | K04A8.6 | ||||||||
| Molecular_name | K04A8.6a | ||||||||
| K04A8.6a.1 | |||||||||
| CE27388 | |||||||||
| K04A8.6b | |||||||||
| CE50130 | |||||||||
| K04A8.6a.2 | |||||||||
| K04A8.6b.1 | |||||||||
| Other_name | F46E10.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| fbxo-11.1 | Person_evidence | WBPerson171 | |||||||
| CELE_K04A8.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | dre-1 | ||||||||
| DB_info | Database | AceView | gene | 5H14 | |||||
| WormQTL | gene | WBGene00001089 | |||||||
| WormFlux | gene | WBGene00001089 | |||||||
| NDB | locus_tag | CELE_K04A8.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001089|UniProtKB=Q94251 | |||||||
| family | PTHR22990 | ||||||||
| NCBI | gene | 179045 | |||||||
| RefSeq | protein | NM_001392535.1 | |||||||
| NM_001380672.1 | |||||||||
| SwissProt | UniProtAcc | Q94251 | |||||||
| TrEMBL | UniProtAcc | A0A0K3AS68 | |||||||
| UniProt_GCRP | UniProtAcc | Q94251 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 14 Mar 2007 09:19:48 | WBPerson2970 | Event | Acquires_merge | WBGene00019377 | ||||
| Name_change | Sequence_name | K04A8.6 | |||||||
| 3 | 12 Jan 2023 20:48:33 | WBPerson51134 | Name_change | CGC_name | dre-1 | ||||
| Other_name | fbxo-11.1 | ||||||||
| Acquires_merge | WBGene00019377 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dre | ||||||||
| Allele (179) | |||||||||
| Strain | WBStrain00001341 | ||||||||
| WBStrain00002251 | |||||||||
| WBStrain00036922 | |||||||||
| WBStrain00037225 | |||||||||
| WBStrain00000025 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00015268 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associatedwith vitiligo and otitis media) that is required, in conjunction withDAF-12 and its partners, for global developmental timing of thetransistion from larval to adult cell fates; DRE-1 has an N-terminalF-box domain, three central tandem C-terminal CASH domains, and aC-terminal zinc finger; hypomorphic dre-1 mutations are syntheticallyheterochronic with loss-of-function daf-12 alleles, inducing defectivedistal tip cell migration and precocious fusion of seam cells; fivedifferent hypomorphic dre-1 alleles alter conserved glycine residues inthe CASH domain region, whereas the null dre-1(hd60) allele is lethal atthe three-fold embryo stage; DRE-1 is expressed in many tissues,including epidermal and distal tip cells, and localizes to both nucleusand cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fedRNAi) induces defects at all four molts; dre-1 also has syntheticphenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-likeenhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), orrbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do theirhuman orthologs; DRE-1 affects lin-29 expression, and is suppressed bylin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3. | Paper_evidence | WBPaper00012854 | |||||
| WBPaper00029151 | |||||||||
| WBPaper00029159 | |||||||||
| WBPaper00029160 | |||||||||
| WBPaper00029161 | |||||||||
| WBPaper00029162 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 12 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable zinc ion binding activity. Involved in several processes, including mesodermal cell migration; nematode larval development; and positive regulation of apoptotic process involved in development. Located in cytoplasm and nucleus. Expressed in several structures, including P5.ppp; gonad; hypodermis; non-striated muscle; and vulva. Human ortholog(s) of this gene implicated in breast carcinoma; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Is an ortholog of human FBXO11 (F-box protein 11). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13590) | ||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13590) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13590) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13590) | ||||||
| Molecular_info | Corresponding_CDS | K04A8.6a | |||||||
| K04A8.6b | |||||||||
| Corresponding_transcript | K04A8.6a.1 | ||||||||
| K04A8.6a.2 | |||||||||
| K04A8.6b.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000395 | ||||||||
| WBCnstr00000396 | |||||||||
| WBCnstr00000397 | |||||||||
| WBCnstr00000401 | |||||||||
| WBCnstr00002234 | |||||||||
| WBCnstr00004264 | |||||||||
| WBCnstr00017520 | |||||||||
| WBCnstr00019163 | |||||||||
| WBCnstr00037087 | |||||||||
| Construct_product | WBCnstr00000395 | ||||||||
| WBCnstr00000396 | |||||||||
| WBCnstr00000397 | |||||||||
| WBCnstr00000401 | |||||||||
| WBCnstr00019163 | |||||||||
| WBCnstr00037087 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (172) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | V | Position | 0.05417 | Error | 0.006328 | |||
| Positive | Positive_clone | K04A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | dre-1 was found in an EMS screen for daf-12 redundant functions [Fielenbach N][030331 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
