WormBase Tree Display for Gene: WBGene00000996
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| WBGene00000996 | SMap | S_parent | Sequence | F49E8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dif-1 | Person_evidence | WBPerson8 | |||||
| Sequence_name | F49E8.5 | ||||||||
| Molecular_name | F49E8.5 | ||||||||
| F49E8.5.1 | |||||||||
| CE28408 | |||||||||
| F49E8.5.2 | |||||||||
| Other_name | slc-25A20 | Person_evidence | WBPerson555 | ||||||
| CELE_F49E8.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | dif-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 26 Apr 2016 15:37:44 | WBPerson2970 | Name_change | Other_name | slc-25A20 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dif | ||||||||
| Allele (32) | |||||||||
| Legacy_information | [Ahringer J] maternal-effect embryonic lethal (mn); embryos arrest at the completion of gastrulation with little or no tissue differentiation; e2562 and e2577 are apparantly null alleles; e2591 is cold-sensitive, with 100% dead eggs at 15C but is variably viable, and sometimes dumpy at 25C. NA5. | ||||||||
| [C.elegansII] e2562 : maternal-effect embryonic lethal (mn); embryos arrest at the completion of gastrulation with little or no tissue differentiation; probable null. OA4: e2577 (similar), e2591cs (100% dead eggs at 15C, variably viable and sometimes dumpy at 25C; TSP hrs 5-8embryo), etc. Cloned: 1.2 kb transcript, present at all stages;encodes predicted 312 aa protein with similarity to mitochondrial carrier proteins. [Ahringer 1995] | |||||||||
| Strain | WBStrain00004627 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP4228 | ||||||||
| Ortholog (46) | |||||||||
| Paralog (35) | |||||||||
| Structured_description | Concise_description | dif-1 encodes a putative mitochondrial solute carrier, orthologous to human SLC25A20 (OMIM:212138, mutated in carnitine-acylcarnitine translocase deficiency) that is required for the maintenance of embryonic tissue differentiation and viability; expressed throughout development and in the intestinal cells and hypodermis of the embryo. | Paper_evidence | WBPaper00002188 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable acyl carnitine transmembrane transporter activity. Involved in mitochondrial transport. Located in mitochondrial envelope. Expressed in intestine. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Is an ortholog of human SLC25A20 (solute carrier family 25 member 20). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111585 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1421) | ||||
| Molecular_info | Corresponding_CDS | F49E8.5 | |||||||
| Corresponding_transcript | F49E8.5.1 | ||||||||
| F49E8.5.2 | |||||||||
| Other_sequence (52) | |||||||||
| Associated_feature | WBsf651923 | ||||||||
| WBsf230293 | |||||||||
| WBsf230294 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00015334 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047872 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090632 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077274 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030258 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077288 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047873 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr628 | ||||||||
| Expr629 | |||||||||
| Expr1017246 | |||||||||
| Expr1030621 | |||||||||
| Expr1151702 | |||||||||
| Expr2010927 | |||||||||
| Expr2029166 | |||||||||
| Drives_construct | WBCnstr00037149 | ||||||||
| Construct_product | WBCnstr00037149 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | IV | Position | 3.35417 | Error | 0.001455 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | stDf7 | |||||||
| Positive_clone | F49E8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| T08G12 | |||||||||
| Mapping_data | Multi_point | 2022 | |||||||
| 2023 | |||||||||
| 2024 | |||||||||
| 2025 | |||||||||
| 2026 | |||||||||
| 4190 | |||||||||
| 4439 | |||||||||
| Pos_neg_data | 5935 | ||||||||
| Reference (11) | |||||||||
| Method | Gene |
