cyd-1 encodes a cyclin D homolog that is required for escape from G1 cycle arrest in postembryonic blast cells, affects movement and larval viability, and may physically interact with CDK-46 and CKI-1; expressed embryonically primarily in the head, ventral cord, tail, and is later expressed primarily in the seam cells and in the somatic gonad.
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including regulation of cell cycle process; regulation of cell division; and reproductive process. Acts upstream of or within nematode male tail tip morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; hypodermis; intestine; neurons; and vulva. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human CCND3 (cyclin D3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.