WormBase Tree Display for Gene: WBGene00000781

WBGene00000781 Evidence: Paper_evidence: WBPaper00001510
  SMap: S_parent: Sequence: C52E4
  Identity: Version: 1
    Name: CGC_name: cpr-1
      Sequence_name: C52E4.1
      Molecular_name: C52E4.1
        C52E4.1.1
        CE31896
      Other_name: CPROT/1
        gcp-1
        CELE_C52E4.1 Accession_evidence: NDB BX284605
      Public_name: cpr-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
              Name_change: Sequence_name: C52E4.1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpr
    Allele (24)
    Legacy_information: [C.elegansII] NMK. Encodes 329 aa protein (pka gcp-1) with 40-50% identity to cysteine proteases; 1.1 kb transcript intestine specific, present in larvae and adults, not embryos. [Ray and McKerrow 1992]
    Strain: WBStrain00031962
    RNASeq_FPKM (74)
    GO_annotation: 00040331
      00040332
      00040333
      00040334
      00040335
      00040336
      00040337
      00107782
      00107783
    Ortholog (58)
    Paralog (28)
    Structured_description: Concise_description: cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. Paper_evidence: WBPaper00001510
            WBPaper00002373
            WBPaper00011712
            WBPaper00022817
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human CTSB (cathepsin B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (10)
  Molecular_info: Corresponding_CDS: C52E4.1
    Corresponding_CDS_history: C52E4.1:wp87
    Corresponding_transcript: C52E4.1.1
    Other_sequence (143)
    Associated_feature: WBsf977952 Paper_evidence: WBPaper00003232
      WBsf977953 Paper_evidence: WBPaper00003232
      WBsf977954 Paper_evidence: WBPaper00003232
      WBsf977955 Paper_evidence: WBPaper00003232
      WBsf1001494
      WBsf1001495
      WBsf1020522
      WBsf232581
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr621
      Expr681
      Expr682
      Expr1011903
      Expr1030484
      Expr1147006
      Expr2010502
      Expr2028742
    Drives_construct: WBCnstr00011019
      WBCnstr00012451
      WBCnstr00015099
      WBCnstr00015100
      WBCnstr00020174
      WBCnstr00037281
    Construct_product: WBCnstr00037281
    Antibody: WBAntibody00001241
    Microarray_results (21)
    Expression_cluster (421)
    Interaction: WBInteraction000030181
      WBInteraction000105218
      WBInteraction000105907
      WBInteraction000117649
      WBInteraction000118552
      WBInteraction000137023
      WBInteraction000137468
      WBInteraction000137988
      WBInteraction000147169
      WBInteraction000148128
      WBInteraction000160842
      WBInteraction000164847
      WBInteraction000170265
      WBInteraction000170266
      WBInteraction000179533
      WBInteraction000183864
      WBInteraction000190421
      WBInteraction000193395
      WBInteraction000195237
      WBInteraction000196476
      WBInteraction000196756
      WBInteraction000198724
      WBInteraction000201524
      WBInteraction000205988
      WBInteraction000206436
      WBInteraction000209559
      WBInteraction000209944
      WBInteraction000217296
      WBInteraction000217706
      WBInteraction000219764
      WBInteraction000221957
      WBInteraction000227199
      WBInteraction000228364
      WBInteraction000229063
      WBInteraction000229549
      WBInteraction000230104
      WBInteraction000230542
      WBInteraction000231518
      WBInteraction000232237
      WBInteraction000234822
      WBInteraction000234939
      WBInteraction000235609
      WBInteraction000235938
      WBInteraction000237057
      WBInteraction000237333
      WBInteraction000242711
      WBInteraction000243189
      WBInteraction000245133
      WBInteraction000245227
      WBInteraction000248203
      WBInteraction000249743
      WBInteraction000256048
      WBInteraction000256648
      WBInteraction000256926
      WBInteraction000258801
      WBInteraction000259670
      WBInteraction000259831
      WBInteraction000260108
      WBInteraction000266676
      WBInteraction000270512
      WBInteraction000273975
      WBInteraction000277482
      WBInteraction000277720
      WBInteraction000279008
      WBInteraction000284645
      WBInteraction000286346
      WBInteraction000287191
      WBInteraction000292835
      WBInteraction000298387
      WBInteraction000298840
      WBInteraction000302094
      WBInteraction000302991
      WBInteraction000304667
      WBInteraction000305024
      WBInteraction000305154
      WBInteraction000306423
      WBInteraction000311349
      WBInteraction000311362
      WBInteraction000314374
      WBInteraction000314518
      WBInteraction000317366
      WBInteraction000318105
      WBInteraction000320531
      WBInteraction000320711
      WBInteraction000325064
      WBInteraction000330229
      WBInteraction000330917
      WBInteraction000332499
      WBInteraction000333242
      WBInteraction000333701
      WBInteraction000334249
      WBInteraction000335782
      WBInteraction000338988
      WBInteraction000342002
      WBInteraction000342963
      WBInteraction000346233
      WBInteraction000346694
      WBInteraction000347269
      WBInteraction000347304
      WBInteraction000348018
      WBInteraction000349676
      WBInteraction000352504
      WBInteraction000353665
      WBInteraction000355053
      WBInteraction000356209
      WBInteraction000356595
      WBInteraction000357132
      WBInteraction000359896
      WBInteraction000361429
      WBInteraction000367155
      WBInteraction000367479
      WBInteraction000367601
      WBInteraction000369801
      WBInteraction000370035
      WBInteraction000370331
      WBInteraction000371599
      WBInteraction000373552
      WBInteraction000377002
      WBInteraction000377337
      WBInteraction000377725
      WBInteraction000378088
      WBInteraction000378580
      WBInteraction000378864
      WBInteraction000384836
      WBInteraction000386207
      WBInteraction000386717
      WBInteraction000394669
      WBInteraction000395164
      WBInteraction000395716
      WBInteraction000397266
      WBInteraction000400117
      WBInteraction000400210
      WBInteraction000405588
      WBInteraction000407753
      WBInteraction000408658
      WBInteraction000410984
      WBInteraction000411480
      WBInteraction000411602
      WBInteraction000412009
      WBInteraction000412180
      WBInteraction000413158
      WBInteraction000413897
      WBInteraction000416179
      WBInteraction000419980
      WBInteraction000420606
      WBInteraction000420996
      WBInteraction000421302
      WBInteraction000421893
      WBInteraction000422678
      WBInteraction000422693
      WBInteraction000424790
      WBInteraction000425257
      WBInteraction000431482
      WBInteraction000434632
      WBInteraction000435235
      WBInteraction000435711
      WBInteraction000439268
      WBInteraction000442449
      WBInteraction000444213
      WBInteraction000444607
      WBInteraction000446122
      WBInteraction000447375
      WBInteraction000449053
      WBInteraction000449828
      WBInteraction000451738
      WBInteraction000453002
      WBInteraction000453421
      WBInteraction000453469
      WBInteraction000454005
      WBInteraction000455903
      WBInteraction000459626
      WBInteraction000459946
      WBInteraction000500997
      WBInteraction000503613
      WBInteraction000503614
      WBInteraction000518602
      WBInteraction000524603
      WBInteraction000524625
      WBInteraction000524626
      WBInteraction000524627
      WBInteraction000551741
      WBInteraction000560244
      WBInteraction000570762
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: 3.54654 Error: 0.001507
    Positive: Positive_clone: C52E4 Inferred_automatically: From sequence, transcript, pseudogene data
        RA#L2
    Mapping_data: Multi_point: 4951
    Pseudo_map_position
  Reference (26)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene