WormBase Tree Display for Gene: WBGene00000781
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| WBGene00000781 | Evidence | Paper_evidence | WBPaper00001510 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C52E4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cpr-1 | |||||||
| Sequence_name | C52E4.1 | ||||||||
| Molecular_name | C52E4.1 | ||||||||
| C52E4.1.1 | |||||||||
| CE31896 | |||||||||
| Other_name | CPROT/1 | ||||||||
| gcp-1 | |||||||||
| CELE_C52E4.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cpr-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Name_change | Sequence_name | C52E4.1 | |||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cpr | ||||||||
| Allele (24) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes 329 aa protein (pka gcp-1) with 40-50% identity to cysteine proteases; 1.1 kb transcript intestine specific, present in larvae and adults, not embryos. [Ray and McKerrow 1992] | ||||||||
| Strain | WBStrain00031962 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00040331 | ||||||||
| 00040332 | |||||||||
| 00040333 | |||||||||
| 00040334 | |||||||||
| 00040335 | |||||||||
| 00040336 | |||||||||
| 00040337 | |||||||||
| 00107782 | |||||||||
| 00107783 | |||||||||
| Ortholog (58) | |||||||||
| Paralog (28) | |||||||||
| Structured_description | Concise_description | cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. | Paper_evidence | WBPaper00001510 | |||||
| WBPaper00002373 | |||||||||
| WBPaper00011712 | |||||||||
| WBPaper00022817 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human CTSB (cathepsin B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:10941 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:12842 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:3068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:4914 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2527) | ||||||
| Molecular_info | Corresponding_CDS | C52E4.1 | |||||||
| Corresponding_CDS_history | C52E4.1:wp87 | ||||||||
| Corresponding_transcript | C52E4.1.1 | ||||||||
| Other_sequence (143) | |||||||||
| Associated_feature | WBsf977952 | Paper_evidence | WBPaper00003232 | ||||||
| WBsf977953 | Paper_evidence | WBPaper00003232 | |||||||
| WBsf977954 | Paper_evidence | WBPaper00003232 | |||||||
| WBsf977955 | Paper_evidence | WBPaper00003232 | |||||||
| WBsf1001494 | |||||||||
| WBsf1001495 | |||||||||
| WBsf1020522 | |||||||||
| WBsf232581 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr621 | ||||||||
| Expr681 | |||||||||
| Expr682 | |||||||||
| Expr1011903 | |||||||||
| Expr1030484 | |||||||||
| Expr1147006 | |||||||||
| Expr2010502 | |||||||||
| Expr2028742 | |||||||||
| Drives_construct | WBCnstr00011019 | ||||||||
| WBCnstr00012451 | |||||||||
| WBCnstr00015099 | |||||||||
| WBCnstr00015100 | |||||||||
| WBCnstr00020174 | |||||||||
| WBCnstr00037281 | |||||||||
| Construct_product | WBCnstr00037281 | ||||||||
| Antibody | WBAntibody00001241 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (421) | |||||||||
| Interaction (183) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | V | Position | 3.54654 | Error | 0.001507 | |||
| Positive | Positive_clone | C52E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| RA#L2 | |||||||||
| Mapping_data | Multi_point | 4951 | |||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
