WormBase Tree Display for Gene: WBGene00000762
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| WBGene00000762 | Evidence | Paper_evidence | WBPaper00013270 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F57B9 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | coq-2 | Person_evidence | WBPerson247 | |||||
| Sequence_name | F57B9.4 | ||||||||
| Molecular_name | F57B9.4a | ||||||||
| F57B9.4a.1 | |||||||||
| CE50155 | |||||||||
| F57B9.4e | |||||||||
| CE32446 | |||||||||
| F57B9.4e.1 | |||||||||
| Other_name | CELE_F57B9.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | coq-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | coq | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00036037 | ||||||||
| WBStrain00028690 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Contained_in_operon | CEOP3404 | ||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00012895 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | coq-2 encodes a putative para-hydroxybenzoate-polyprenyl transferase(UbiA prenyltransferase), orthologous to S. cerevisiae COQ2; COQ-2 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; coq-2 mutants have slowed pharyngeal pumping, andeventually arrest as paralysed larvae before dying; coq-2(RNAi) animalshave reduced levels of coenzyme Q9 and superoxide, and have abnormallylong lifespans; coq-2 mutants are not rescued by dietary coenzyme Q. | Paper_evidence | WBPaper00005863 | |||||
| WBPaper00028316 | |||||||||
| WBPaper00028394 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable 4-hydroxybenzoate decaprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Is an ortholog of human COQ2 (coenzyme Q2, polyprenyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070238 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25223) | ||||
| Molecular_info | Corresponding_CDS | F57B9.4a | |||||||
| F57B9.4e | |||||||||
| Corresponding_CDS_history | F57B9.4a:wp245 | ||||||||
| F57B9.4b:wp245 | |||||||||
| F57B9.4c:wp245 | |||||||||
| F57B9.4d:wp245 | |||||||||
| Corresponding_transcript | F57B9.4a.1 | ||||||||
| F57B9.4e.1 | |||||||||
| Other_sequence (53) | |||||||||
| Associated_feature | WBsf645301 | ||||||||
| WBsf659135 | |||||||||
| WBsf992904 | |||||||||
| WBsf992905 | |||||||||
| WBsf225178 | |||||||||
| WBsf225179 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00048837 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005587 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033019 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022971 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1011584 | ||||||||
| Expr1030468 | |||||||||
| Expr1152590 | |||||||||
| Expr2010462 | |||||||||
| Expr2028702 | |||||||||
| Drives_construct | WBCnstr00037296 | ||||||||
| Construct_product | WBCnstr00037296 | ||||||||
| Microarray_results (41) | |||||||||
| Expression_cluster (75) | |||||||||
| Interaction (20) | |||||||||
| Map_info | Map | III | Position | -0.876426 | Error | 0.003817 | |||
| Positive | Positive_clone | F57B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4970 | |||||||
| 4172 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005863 | ||||||||
| WBPaper00006360 | |||||||||
| WBPaper00011299 | |||||||||
| WBPaper00025408 | |||||||||
| WBPaper00028394 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060049 | |||||||||
| WBPaper00060056 | |||||||||
| WBPaper00062853 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
