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WormBase Tree Display for Gene: WBGene00000524

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Name Class

WBGene00000524SMapS_parentSequenceZK563
IdentityVersion1
NameCGC_nameclc-3
Sequence_nameZK563.4
Molecular_nameZK563.4a
ZK563.4a.1
CE05095
ZK563.4b
CE33749
ZK563.4b.1
Other_nameCELE_ZK563.4Accession_evidenceNDBBX284606
Public_nameclc-3
DB_infoDatabaseAceViewgeneXD992
WormQTLgeneWBGene00000524
WormFluxgeneWBGene00000524
NDBlocus_tagCELE_ZK563.4
NCBIgene180625
RefSeqproteinNM_001029822.7
NM_001029823.6
TrEMBLUniProtAccH2KYF7
Q23532
UniProt_GCRPUniProtAccQ23532
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classclc
Allele (19)
StrainWBStrain00032092
RNASeq_FPKM (74)
GO_annotation00021548
00021549
00021550
00021551
00078776
00107534
Ortholog (22)
Structured_descriptionConcise_descriptionclc-3 encodes a claudin homolog that may regulate ion channels; CLC-3 is worm-specific, with a highly divergent sequence weakly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.Paper_evidenceWBPaper00004961
WBPaper00005946
WBPaper00005975
WBPaper00012762
WBPaper00012856
WBPaper00012941
WBPaper00013626
WBPaper00018356
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to be involved in epithelial cell-cell adhesion. Located in plasma membrane.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSZK563.4a
ZK563.4b
Corresponding_transcriptZK563.4a.1
ZK563.4b.1
Other_sequenceCBC06882_1
Associated_featureWBsf653835
WBsf1004605
WBsf237168
WBsf237169
WBsf237170
Experimental_infoRNAi_resultWBRNAi00038341Inferred_automaticallyRNAi_primary
WBRNAi00059519Inferred_automaticallyRNAi_primary
WBRNAi00081187Inferred_automaticallyRNAi_primary
WBRNAi00022064Inferred_automaticallyRNAi_primary
Expr_patternExpr9465
Expr1011435
Expr1162936
Expr2010043
Expr2028284
Drives_constructWBCnstr00037475
Construct_productWBCnstr00014030
WBCnstr00037475
Microarray_results (22)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032976:dosage_compensated_genes
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:BAG-neuron_embryo_enriched
WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044736:flat_dev_expression
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049626:UNC-75_target
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00051558:aging_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053664:ins-11(tm1053)_downregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055648:male-tail_expressed
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059763:neuron_expressed
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AIA
WBPaper00061340:AIZ
WBPaper00061340:AWB
WBPaper00061340:AWC
WBPaper00061340:hmc
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:RIV
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061527:flp-5-F17C11.2
WBPaper00061651:AIZ_enriched
WBPaper00061651:AWB_enriched
WBPaper00061651:DA9_enriched
WBPaper00061651:PDB_enriched
WBPaper00061651:VA12_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:7_2
WBPaper00065841:7_3
WBPaper00065841:14_0
WBPaper00065841:14_2
WBPaper00065841:19_0
WBPaper00065841:38_0
WBPaper00065841:38_1
WBPaper00065841:38_3
WBPaper00065841:87_0
WBPaper00065841:102_0
WBPaper00065841:104_0
WBPaper00065841:108_0
WBPaper00065841:122_0
WBPaper00065841:132_0
WBPaper00065841:136_0
WBPaper00065841:145_0
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00036286:Pattern_C
WBPaper00037695:LD_3-day
WBPaper00037695:WC_5-day
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
InteractionWBInteraction000133970
WBInteraction000136804
WBInteraction000140913
WBInteraction000314375
WBInteraction000349867
WBInteraction000444156
Map_infoMapXPosition-10.3996Error0.020116
PositivePositive_cloneZK563Inferred_automatically (2)
Mapping_dataMulti_point4219
Pseudo_map_position
ReferenceWBPaper00005946
WBPaper00013424
WBPaper00013425
WBPaper00018356
WBPaper00023962
WBPaper00026406
WBPaper00034662
WBPaper00038444
WBPaper00039831
WBPaper00044402
RemarkSequence connection from [Asano A, Tsukita S]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene