WormBase Tree Display for Gene: WBGene00000516

WBGene00000516 SMap: S_parent: Sequence: T05A6
  Identity: Version: 1
    Name: CGC_name: cki-1 Person_evidence: WBPerson322
      Sequence_name: T05A6.1
      Molecular_name: T05A6.1
        T05A6.1.1
        CE03628
      Other_name: CELE_T05A6.1 Accession_evidence: NDB BX284602
      Public_name: cki-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cki
    Allele (11)
    Strain: WBStrain00035555
      WBStrain00050664
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (25)
    Paralog: WBGene00000517 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
    Structured_description: Concise_description: cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. Paper_evidence: WBPaper00003201
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including gonad development; regulation of cell cycle process; and regulation of cell division. Located in nucleus. Expressed in several structures, including excretory duct; hermaphrodite somatic gonadal cell; hypodermal cell; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); lung carcinoma (multiple); and urinary system cancer (multiple). Is an ortholog of human CDKN1B (cyclin dependent kinase inhibitor 1B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: T05A6.1
    Corresponding_transcript: T05A6.1.1
    Other_sequence: AF179358
      CJC06215_1
    Associated_feature (24)
  Experimental_info: RNAi_result (52)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000933
      WBCnstr00008831
      WBCnstr00010882
      WBCnstr00012156
      WBCnstr00037482
    Construct_product: WBCnstr00000595
      WBCnstr00015480
      WBCnstr00019394
      WBCnstr00021185
      WBCnstr00037482
      WBCnstr00041722
    Antibody: WBAntibody00000980
    Microarray_results (21)
    Expression_cluster (249)
    Interaction (109)
  Map_info: Map: II Position: 0.566619 Error: 0.001788
    Positive: Positive_clone: T05A6 Inferred_automatically (2)
    Mapping_data: Multi_point: 4221
        4222
    Pseudo_map_position
  Reference: WBPaper00003201
    WBPaper00003762
    WBPaper00003829
    WBPaper00004996
    WBPaper00005046
    WBPaper00005137
    WBPaper00005165
    WBPaper00005260
    WBPaper00005298
    WBPaper00005597
    WBPaper00005725
    WBPaper00005880
    WBPaper00006027
    WBPaper00006209
    WBPaper00006391
    WBPaper00010203
    WBPaper00010246
    WBPaper00010462
    WBPaper00010483
    WBPaper00010597
    WBPaper00010681
    WBPaper00010688
    WBPaper00010824
    WBPaper00010878
    WBPaper00011125
    WBPaper00011254
    WBPaper00011272
    WBPaper00015513
    WBPaper00016596
    WBPaper00016903
    WBPaper00017124
    WBPaper00017500
    WBPaper00017802
    WBPaper00018059
    WBPaper00018374
    WBPaper00018376
    WBPaper00018382
    WBPaper00018634
    WBPaper00018635
    WBPaper00018641
    WBPaper00018644
    WBPaper00018965
    WBPaper00019215
    WBPaper00019524
    WBPaper00019697
    WBPaper00019698
    WBPaper00019709
    WBPaper00022321
    WBPaper00022955
    WBPaper00023125
    WBPaper00023144
    WBPaper00023551
    WBPaper00023589
    WBPaper00024034
    WBPaper00024252
    WBPaper00024302
    WBPaper00024303
    WBPaper00024430
    WBPaper00024734
    WBPaper00025091
    WBPaper00025581
    WBPaper00025706
    WBPaper00025825
    WBPaper00026133
    WBPaper00026179
    WBPaper00026839
    WBPaper00026868
    WBPaper00026891
    WBPaper00027234
    WBPaper00027315
    WBPaper00027316
    WBPaper00027347
    WBPaper00027533
    WBPaper00027860
    WBPaper00028464
    WBPaper00028868
    WBPaper00029328
    WBPaper00029347
    WBPaper00029399
    WBPaper00030484
    WBPaper00030511
    WBPaper00030954
    WBPaper00031094
    WBPaper00031331
    WBPaper00032186
    WBPaper00032519
    WBPaper00032556
    WBPaper00033797
    WBPaper00033858
    WBPaper00034279
    WBPaper00034327
    WBPaper00034414
    WBPaper00034720
    WBPaper00035882
    WBPaper00035996
    WBPaper00036770
    WBPaper00036970
    WBPaper00036993
    WBPaper00037728
    WBPaper00037796
    WBPaper00038700
    WBPaper00039243
    WBPaper00039353
    WBPaper00039805
    WBPaper00041410
    WBPaper00042823
    WBPaper00042825
    WBPaper00044900
    WBPaper00047302
    WBPaper00048714
    WBPaper00052227
    WBPaper00052235
    WBPaper00057940
    WBPaper00060275
    WBPaper00060798
    WBPaper00060839
    WBPaper00062830
    WBPaper00063051
    WBPaper00063054
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene