WormBase Tree Display for Gene: WBGene00000467
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WBGene00000467 | SMap | S_parent | Sequence | F52B5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cep | ||||||
Allele (54) | |||||||
Strain | WBStrain00022753 | ||||||
WBStrain00034662 | |||||||
WBStrain00034663 | |||||||
WBStrain00034811 | |||||||
WBStrain00035557 | |||||||
WBStrain00040683 | |||||||
WBStrain00004786 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (45) | |||||||
Ortholog (17) | |||||||
Structured_description | Concise_description | cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. | Paper_evidence | WBPaper00004589 | |||
WBPaper00004919 | |||||||
WBPaper00004952 | |||||||
WBPaper00012759 | |||||||
WBPaper00012806 | |||||||
WBPaper00013586 | |||||||
WBPaper00013634 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in germ cell nucleus; nucleolus; and nucleoplasm. Expressed in Z2; Z3; germ line; pharyngeal cell; and pharynx. Used to study cancer. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00004952 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 03 Feb 2020 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000735 | ||||||
Molecular_info | Corresponding_CDS | F52B5.5a | |||||
F52B5.5b | |||||||
Corresponding_CDS_history | F52B5.5:wp68 | ||||||
Corresponding_transcript | F52B5.5a.1 | ||||||
F52B5.5b.1 | |||||||
F52B5.5b.2 | |||||||
F52B5.5b.3 | |||||||
F52B5.5b.4 | |||||||
Other_sequence | Tcir_isotig12051 | ||||||
CBC03970_1 | |||||||
Associated_feature | WBsf656624 | ||||||
WBsf976837 | |||||||
WBsf218143 | |||||||
Gene_product_binds | WBsf034249 | ||||||
WBsf034250 | |||||||
Transcription_factor | WBTranscriptionFactor000114 | ||||||
Experimental_info (11) | |||||||
Map_info | Map | I | Position | 2.73569 | Error | 0.00602 | |
Positive | Positive_clone | F52B5 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4212 | |||||
4897 | |||||||
Pseudo_map_position | |||||||
Reference (251) | |||||||
Picture | WBPicture0000013091 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
[wm99ab616], [wm2001p535] and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog. | |||||||
Method | Gene |