WormBase Tree Display for Gene: WBGene00000435
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| WBGene00000435 | SMap | S_parent | Sequence | W03A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-10 | Person_evidence | WBPerson83 | |||||
| Sequence_name | W03A3.1 | ||||||||
| Molecular_name | W03A3.1 | ||||||||
| W03A3.1.1 | |||||||||
| CE07563 | |||||||||
| Other_name | mig-11 | ||||||||
| CELE_W03A3.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | ceh-10 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (48) | |||||||||
| Legacy_information | [C.elegansII] NMK. 1.2 kb transcript, encodes 344 aa Paired-like class homeoprotein; extensive similarity to mouse Chx10, goldfish Vsx-1. ceh-10:lacZ expressed maximally in embryo,from250-300 cell stage, lower in larvae, in certain neuronal nuclei (interneurons AIY, AIN; sensoryneurons CEPD, motor neurons RID, RMED; CAN cellsetc.). Transgene can induce defects in CAN cell migration and withered tail phenotype. [Hawkins and McGhee 1990; Svendsen and McGhee 1995; JM] | ||||||||
| [C.elegansII] NMK. 1.2 kb transcript, encodes 344 aa Paired-like class homeoprotein; extensive similarity to mouse Chx10, goldfish Vsx-1. ceh-10:lacZ expressed maximally in embryo, from 250-300 cell stage, lower in larvae, in certain neuronal nuclei (interneurons AIY, AIN; sensory neurons CEPD, motor neurons RID, RMED; CAN cells etc.). Transgene can induce defects in CAN cell migration and withered tail phenotype. [Hawkins and McGhee 1990; Svendsen and McGhee 1995; JM] | |||||||||
| [Forrester WC] gm120 homozygotes viable, occasionally Unc, Egl, Muv, withered tail. G to A change at first intron donor. OA6: gm127 resembles gm120, gm58 etc all die as Clr larvae. gm100, gm133 nonsense mutations. | |||||||||
| [C.elegansII] ct78 : defective CAN migrations; other migrations defective at low penetrance. [LK; CX] | |||||||||
| Strain | WBStrain00028735 | ||||||||
| WBStrain00003961 | |||||||||
| WBStrain00033854 | |||||||||
| WBStrain00050483 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons. | Paper_evidence | WBPaper00001346 | |||||
| WBPaper00002186 | |||||||||
| WBPaper00002978 | |||||||||
| WBPaper00004727 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalapppaa; CAN; head neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in eye disease (multiple). Is an ortholog of human VSX2 (visual system homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060839 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) | ||||
| DOID:1432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) | ||||||
| DOID:10126 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) | ||||||
| EFO:MONDO:0000170 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1975) | ||||||
| DOID:0110855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) | ||||||
| DOID:2566 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12723) | ||||||
| Molecular_info | Corresponding_CDS | W03A3.1 | |||||||
| Corresponding_transcript | W03A3.1.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf658992 | ||||||||
| WBsf978897 | |||||||||
| WBsf992534 | |||||||||
| WBsf224996 | |||||||||
| Transcription_factor | WBTranscriptionFactor000033 | ||||||||
| WBTranscriptionFactor000606 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00084771 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027655 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075607 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019528 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054638 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084769 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005463 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000885 | ||||||||
| WBCnstr00000886 | |||||||||
| WBCnstr00001673 | |||||||||
| WBCnstr00001674 | |||||||||
| WBCnstr00001675 | |||||||||
| WBCnstr00005975 | |||||||||
| WBCnstr00012841 | |||||||||
| WBCnstr00014232 | |||||||||
| WBCnstr00020303 | |||||||||
| WBCnstr00020304 | |||||||||
| Construct_product | WBCnstr00001599 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (102) | |||||||||
| Interaction (61) | |||||||||
| Map_info | Map | III | Position | -1.44616 | Error | 0.00013 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | JM#L1003 | |||||||
| W03A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3715 | |||||||
| 1499 | |||||||||
| 1500 | |||||||||
| 1501 | |||||||||
| 1502 | |||||||||
| 4431 | |||||||||
| Pos_neg_data | 4233 | ||||||||
| 4234 | |||||||||
| Reference (55) | |||||||||
| Remark | Data extracted from Forrester et al. (1998) | ||||||||
| mig-11 fused into this. Canonical allele ct78 is a deletion of the C-terminus of ceh-10 and has anomalous complementation . ct78 complements CAN-defective ceh-10 null alleles but fails to complement ceh-10 alleles with respect to ttx-3 expression. [Hobert O, Wenick AS, Buelow H] | |||||||||
| Method | Gene |
