WormBase Tree Display for Gene: WBGene00000149
expand all nodes | collapse all nodes | view schema
| WBGene00000149 | SMap | S_parent | Sequence | C42D8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | apl-1 | Person_evidence | WBPerson369 | |||||
| Sequence_name | C42D8.8 | ||||||||
| Molecular_name | C42D8.8a | ||||||||
| C42D8.8a.1 | |||||||||
| CE04209 | |||||||||
| C42D8.8b | |||||||||
| CE27845 | |||||||||
| C42D8.8b.1 | |||||||||
| Other_name | uvt-4 | ||||||||
| CELE_C42D8.8 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | apl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00037623 | ||||
| WBPaper00040923 | |||||||||
| WBPaper00041335 | |||||||||
| Accession_evidence | OMIM | 104300 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Feb 2019 00:00:00 | ||||||||
| Potential_model | DOID:11832 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | |||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:0081292 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:0070028 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:1561 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:0080348 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| DOID:824 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:620) | ||||||
| Disease_relevance | C. elegans is a model system to study the normal function of APP (Amyloid precursor protein) and it''s cleavage product beta-amyloid peptide, and their role in Alzheimer''s disease; elegans apl-1/APP, is essential for neuronal survival, either loss or overexpression of APL-1 causes lethality; neuronal overexpression of human beta-amyloid peptide in C. elegans, causes learning defects and muscle paralysis and intracellular accumulation of A-beta; further, reduced insulin/IGF-1 signaling protects against the pathogenic effects of A-beta. | Homo sapiens | Paper_evidence | WBPaper00040364 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Jun 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000102 | ||||||||
| Models_disease_asserted | WBDOannot00000630 | ||||||||
| WBDOannot00000631 | |||||||||
| Molecular_info | Corresponding_CDS | C42D8.8a | |||||||
| C42D8.8b | |||||||||
| Corresponding_transcript | C42D8.8a.1 | ||||||||
| C42D8.8b.1 | |||||||||
| Other_sequence (84) | |||||||||
| Associated_feature (26) | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (27) | |||||||||
| Construct_product (29) | |||||||||
| Antibody | WBAntibody00000473 | ||||||||
| WBAntibody00001222 | |||||||||
| WBAntibody00001223 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (232) | |||||||||
| Interaction (104) | |||||||||
| Map_info | Map | X | Position | -6.17972 | Error | 0.002702 | |||
| Positive | Positive_clone | C42D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| NY#L14A | |||||||||
| Mapping_data | Multi_point | 4158 | |||||||
| Pseudo_map_position | |||||||||
| Reference (84) | |||||||||
| Remark | Map X | ||||||||
| Following advice from JAH, uvt-4 was merged into apl-1 with apl-1 being kept as the primary name. These two genes were equivalent, though uvt is older. However, it was felt that more important recent work has been done using the name apl-1. Some of the information attached to the current apl-1 object therefore has been taken from the old uvt-4 Locus object. | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
