WormBase Tree Display for Gene: WBGene00000039
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| WBGene00000039 | Evidence | Person_evidence | WBPerson1106 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C42D8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | acn-1 | Person_evidence | WBPerson266 | |||||
| Sequence_name | C42D8.5 | ||||||||
| Molecular_name | C42D8.5 | ||||||||
| C42D8.5.1 | |||||||||
| CE30627 | |||||||||
| Other_name | CELE_C42D8.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | acn-1 | ||||||||
| DB_info | Database | AceView | gene | XF712 | |||||
| WormQTL | gene | WBGene00000039 | |||||||
| WormFlux | gene | WBGene00000039 | |||||||
| NDB | locus_tag | CELE_C42D8.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000039|UniProtKB=Q18581 | |||||||
| family | PTHR10514 | ||||||||
| NCBI | gene | 180780 | |||||||
| RefSeq | protein | NM_001029282.7 | |||||||
| SwissProt | UniProtAcc | Q18581 | |||||||
| UniProt_GCRP | UniProtAcc | Q18581 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | acn | ||||||||
| Allele (85) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | acn-1 encodes an ACE-like protein required for larval development and adult morphogenesis, and probably for cell fusion in larval seam cells; ACN-1 lacks not only the HExxH consensus metallopeptidase motif, but also other active site residues found in the sequence HEAI/VxD of mammalian and insect ACEs; acn-1 is expressed in hypodermal cells, vulval precursor cells, and ray papillae in the male tail; the hypodermal expression of acn-1 appears to be controlled by nhr-23 and nhr-25. | Paper_evidence | WBPaper00006295 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metallopeptidase activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode male tail tip morphogenesis. Acts upstream of or within with a negative effect on plasma membrane fusion. Predicted to be located in plasma membrane. Expressed in excretory gland cell; hypodermis; vulva; and in male. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of human ACE2 (angiotensin converting enzyme 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (65) | ||||||||
| Molecular_info | Corresponding_CDS | C42D8.5 | |||||||
| Corresponding_CDS_history | C42D8.5:wp129 | ||||||||
| C42D8.5b:wp271 | |||||||||
| Corresponding_transcript | C42D8.5.1 | ||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf718578 | ||||||||
| WBsf1005175 | |||||||||
| WBsf1005176 | |||||||||
| WBsf1022909 | |||||||||
| WBsf1022910 | |||||||||
| WBsf237348 | |||||||||
| WBsf237349 | |||||||||
| WBsf237350 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr2720 | ||||||||
| Expr3694 | |||||||||
| Expr1022196 | |||||||||
| Expr1030019 | |||||||||
| Expr1146352 | |||||||||
| Expr2009163 | |||||||||
| Expr2027400 | |||||||||
| Drives_construct | WBCnstr00006891 | ||||||||
| WBCnstr00010917 | |||||||||
| WBCnstr00011605 | |||||||||
| WBCnstr00037778 | |||||||||
| Construct_product | WBCnstr00010917 | ||||||||
| WBCnstr00037778 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (301) | |||||||||
| Interaction (83) | |||||||||
| Map_info | Map | X | Position | -6.19435 | Error | 0.001326 | |||
| Positive | Positive_clone | C42D8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4158 | |||||||
| 5406 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
