WormBase Tree Display for Disease_model_annotation: WBDOannot00001354
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| WBDOannot00001354 | Disease_term | DOID:0050589 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00000001 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Experimental_condition | Inducing_agent | Pseudomonas aeruginosa supernatant | |
| Modifier_info | Modifier_molecule | WBMol:00008000 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00064274 | ||
| Disease_model_description | Worms fed the supernatant of P. aeruginosa, an intestinal pathogen, mimics Inflammatory Bowel Disease (IBD) and serves as an experimental system to study intestinal permeability dysfunction; treatment with schisandrin C (a dibenzocyclooctadiene lignan from Schisandra chinensis) successfully ameliorates intestinal barrier dysfunction in this C. elegans IBD model without significant side effects. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 01 Nov 2022 00:00:00 |
