WormBase Tree Display for Disease_model_annotation: WBDOannot00000990
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| WBDOannot00000990 | Disease_term | DOID:332 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Genotype | WBGenotype00000067 | |
| Association_type | is_exacerbated_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_gene | WBGene00000474 | |
| Modifier_association_type | condition_exacerbated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00061562 | ||
| Disease_model_description | Proteostasis deficits in germline stem cells in C. elegans leads to the triggering of the unfolded protein response of the mitochondria in the soma, promoting somatic mitochondrial fragmentation and aggregation of proteins linked with neurodegenerative diseases such as Huntingtons and amyotrophic lateral sclerosis (ALS); knockdown of germline-specific CEYs (cey-3) increases aggregation of ALS-related mutant FUS(P525L) variant in C. elegans neurons (detected by anti-FUS antibody). | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 09 Aug 2021 00:00:00 |
