WormBase Tree Display for Disease_model_annotation: WBDOannot00000918
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| WBDOannot00000918 | Disease_term | DOID:0080933 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00000001 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Other_modifier | Triple mutant immunoglobulin light chain (LC mH6; V47L, T70N,G75T) | |
| Modifier_association_type | condition_exacerbated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00059017 | ||
| Disease_model_description | Fibrillar deposits of monoclonal immunoglobulin light chains (LCs) are implicated in light chain amyloidosis (AL); when worms were exposed to an engineered triple mutant immunoglobulin light chain dimer (LC mH6; V47L, T70N,G75T), pharyngeal activity was significantly impaired, whereas the native LC H6 dimer did not affect pharyngeal function. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 01 Jun 2021 00:00:00 |
