WormBase Tree Display for Analysis: Microarray_Study.WBPaper00037147.ce.mr
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| Microarray_Study.WBPaper00037147.ce.mr | DB_info | Database | GEO | GSE22383 |
|---|---|---|---|---|
| Title | Insulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans. | |||
| Description | The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and HSF-1 are key effectors of the longevity phenotype. We demonstrate that increased intrinsic thermotolerance, due to lower ILS, is not dependent on stress induced HSF-1 transcriptional responses but instead requires active protein translation. Translation profiling experiments reveal genes that are post-transcriptionally regulated in response to altered ILS during heat shock in a DAF-16-dependent manner. Furthermore, several novel proteins are specifically required for ILS effects on thermotolerance. We propose that lowered-ILS results in DAF-16-induced metabolic and physiological changes that precondition a translational response to modulated survival under acute stress. | |||
| Category | response to temperature stimulus | |||
| Microarray_experiment (72) | ||||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00037147 |
