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WormBase Tree Display for Analysis: Microarray_Study.WBPaper00034757.ce.mr

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Name Class

Microarray_Study.WBPaper00034757.ce.mrDB_infoDatabaseGEOGSE9301
TitleSKN-1-dependent oxidative stress response in C. elegans
DescriptionOxidative stress may play a role in normal aging. SKN-1 is a transcription factor necessary for intestine development in Caenorhabditis elegans, which also regulates the response to oxidative stress post-embryonically. Using DNA microarrays, we found that oxidative stress induces the antioxidant response, the heat shock response, and detoxification genes, while the expression of genes involved in homeostasis, development, and reproduction were decreased. Both up-regulated and down-regulated genes can be wholly, partially, or not at all dependent on SKN-1 action. However, induction of the heat shock response by oxidative stress was not affected by SKN-1 removal. Keywords: stress response
Categoryresponse to hypoxia
Microarray_experimentWBPaper00034757:control_no_stress_1
WBPaper00034757:control_no_stress_2
WBPaper00034757:control_no_stress_3
WBPaper00034757:control_no_stress_4
WBPaper00034757:oxidative_stress_1
WBPaper00034757:oxidative_stress_2
WBPaper00034757:oxidative_stress_3
WBPaper00034757:oxidative_stress_4
WBPaper00034757:skn-1_RNAi_oxidative_stress_1
WBPaper00034757:skn-1_RNAi_oxidative_stress_2
WBPaper00034757:skn-1_RNAi_oxidative_stress_3
Species_in_analysisCaenorhabditis elegans
ReferenceWBPaper00034757