WormBase Tree Display for Analysis: Microarray_Study.WBPaper00031070.ce.mr
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| Microarray_Study.WBPaper00031070.ce.mr | DB_info | Database | GEO | GSE8659 |
|---|---|---|---|---|
| Title | Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants | |||
| Description | RRF-3 and ERI-1 are first identified proteins required for accumulation of at least some endogenous secondary siRNAs in C.elegans. Genome wide gene expression analysis was performed on L4 stage rrf-3 and eri-1 mutant C. elegans to study effects caused by loss of these proteins. Mutant rrf-3 and eri-1 strains exhibited similar expression patterns when compared to N2 wild type, while 72 transcripts were found to be co-overexpressed and 4 transcripts co-underexpressed (> 2-fold, p< 0.05). Ontology analysis indicated many of the gene products were associated with protein phosphorylation and sperm function. These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in a siRNA pathway and may indicate biological processes that are related to endo-siRNAs. Keywords: Mutant vs. wild type -comparison | |||
| Category | RNA interference | |||
| Microarray_experiment | WBPaper00031070:N2_1 | |||
| WBPaper00031070:N2_2 | ||||
| WBPaper00031070:N2_3 | ||||
| WBPaper00031070:NL2099_1 | ||||
| WBPaper00031070:NL2099_2 | ||||
| WBPaper00031070:NL2099_3 | ||||
| WBPaper00031070:GR1373_1 | ||||
| WBPaper00031070:GR1373_2 | ||||
| WBPaper00031070:GR1373_3 | ||||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00031070 |
