WormBase Tree Display for Analysis: Microarray_Study.WBPaper00005056.ce.mr
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| Microarray_Study.WBPaper00005056.ce.mr | DB_info | Database | GEO | GSE3681 |
|---|---|---|---|---|
| Title | PHA-4 organogenesis | |||
| Description | The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes. A genotyping experiment design type classifies an individual or group of individuals on the basis of alleles, haplotypes, SNP's. Keywords: genotyping_design | |||
| Category | WT vs. mutant | |||
| Microarray_experiment | [cgc5056]:par-1_skn-1_ratio | |||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00005056 |
