WormBase Tree Display for Gene: HGNC:3393
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| HGNC:3393 | Identity | Name | CGC_name | Ephb2 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (20) | ||||||
| Public_name | Ephb2 | |||||
| DB_info | Database | HGNC | id | 3393 | ||
| AGR | cURI | HGNC:3393 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000133216 | ||||
| UniProt | UniProt_AC | P29323 | ||||
| OMIM | gene | 600997 | ||||
| DO | id | DOID:526 | ||||
| DOID:2218 | ||||||
| DOID:1561 | ||||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00006868 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] | Inferred_automatically | AGR_import |
