WormBase Tree Display for GO_term: GO:0036498
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| GO:0036498 | Name | IRE1-mediated unfolded protein response | |
|---|---|---|---|
| Definition | The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. | ||
| Synonym | Broad | IRE1 signal transduction pathway | |
| Exact | endoplasmic reticulum unfolded protein response; IRE1 signaling | ||
| IRE1 branch of UPR | |||
| UPR signaling by IRE1 stress sensor | |||
| Narrow | IRE1alpha unfolded protein response | ||
| IRE1p unfolded protein response | |||
| Related | ERN1-mediated unfolded protein response | ||
| inositol-requiring enzyme 1-mediated unfolded protein response | |||
| inositol-requiring transmembrane kinase/endonuclease signal transduction | |||
| IRE1 signaling in response to endoplasmic reticulum stress | |||
| Status | Valid | ||
| Type | Biological_process | ||
| Parent | Instance_of | GO:0030968 | |
| Attributes_of | Index | Ancestor (22) | |
| GO_annotation (143) | |||
| Version | Gene Ontology releases/2023-11-15 |
