WormBase Tree Display for GO_term: GO:0035195

GO:0035195 Name: miRNA-mediated post-transcriptional gene silencing
  Definition: A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
  Synonym: Broad: miRNA-mediated gene silencing
    Exact: gene silencing by microRNA
      gene silencing by miRNA
      microRNA-mediated gene silencing
  Status: Valid
  Type: Biological_process
  Child: Instance: GO:0035278
      GO:0035279
    Component: GO:0035281
  Parent: Instance_of: GO:0035194
  Attributes_of: Index: Ancestor (24)
      Descendant: GO:0035278
        GO:0035279
        GO:0035281
        GO:0090624
    GO_annotation: 00106155
      00106168
      00106174
      00106192
      00106241
      00106250
      00106264
      00036982
      00064392
  Version: Gene Ontology releases/2023-11-15