WormBase Tree Display for Expr_pattern: Expr9095
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| Expr9095 | Expression_of | Gene | WBGene00013606 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00013606 | |||
| Expression_data | Anatomy_term | WBbt:0004017 | Certain | |
| GO_term | GO:0005634 | |||
| Subcellular_localization | Expressed in nucleus | |||
| Type | Antibody | |||
| Pattern | In early embryos, CAND-1 is expressed in all cells, predominantly in the nucleus. Embryonic staining is strongest during early stages and is reduced in late-stage embryos. The observation of CAND-1 protein in the one-cell stage zygote indicates that CAND-1 is provided as maternal product by the hermaphrodite parent. During larval stages, CAND-1 is observed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. CAND-1 is also observed in a subset of non-proliferative tissues, including hypodermal cells, rectal epithelia and neuronal cells in the head and tail. In older adults, anti-CAND-1 staining is restricted to the intestine and germline, with the strongest staining in oocyte nuclei. In younger adults, faint vulval cell staining is observed, potentially reflecting the perdurance of CAND-1 protein from the L4 larval stage. The absence of CAND-1 expression in the majority of adult somatic tissues suggests that CAND-1 is not required for tissue homeostasis in the adult. | |||
| Remark | Picture: Fig 2. | |||
| RNAi depletion of CAND-1 significantly decreased the anti-CAND-1 signal, indicating that the staining is specific. | ||||
| Reference | WBPaper00036713 | |||
| Antibody_info | WBAntibody00002151 |
