WormBase Tree Display for Expr_pattern: Expr9094
expand all nodes | collapse all nodes | view schema
| Expr9094 | Expression_of | Gene | WBGene00010056 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00010056 | |||
| Expression_data | Anatomy_term | WBbt:0005784 | Certain | |
| GO_term | GO:0005694 | |||
| GO:0043073 | ||||
| Subcellular_localization | The SMC-6 protein was detected by indirect immunofluorescence microscopy in the nuclei of germ cells throughout the adult hermaphrodite gonad. Beginning at the distal tip region of the gonad, SMC-6 staining is detected in the nucleus of germ cells in mitotic proliferation, pre-meiotic S phase and in the early stages of meiosis (the transition zone), which are equivalent to leptotene and zygotene. SMC-6 staining became more enriched on chromosomes at pachytene, which coincided with the timing of meiotic DSB repair. The SMC-6 immunofluorescence became more intense as the germ cells exited pachytene and progressed through the diplotene and diakinesis stages of prophase. The pachytene and diakinesis staining of SMC-6 was specifically disrupted by the smc-6(ok3294) mutation. In addition to germ cell staining, immunostaining was detected in somatic cells during early embryogenesis. | |||
| Type | Antibody | |||
| Picture | WBPicture0000007464 | |||
| Remark | Picture: Fig 2, Fig S1. | |||
| Reference | WBPaper00036709 | |||
| Antibody_info | WBAntibody00002150 |
