WormBase Tree Display for Expr_pattern: Expr57
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| Expr57 | Expression_of | Gene | WBGene00001949 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00001949 | |||
| Clone | C01H6 | |||
| F21E8 | ||||
| K07G5 | ||||
| Expression_data | Life_stage | WBls:0000024 | ||
| WBls:0000003 | ||||
| WBls:0000038 | ||||
| WBls:0000027 | ||||
| WBls:0000035 | ||||
| WBls:0000041 | ||||
| Anatomy_term | WBbt:0003679 | Partial | ||
| Type | Antibody | to CeE12/Da homologue to a ubiquitous transcription factor | ||
| Reporter_gene | ||||
| Pattern | Antibody staining: nuclear stained blastomeres from at least 2 cell stage on. All blastomeres stain up to about the 200 cell stage. Pattern then becomes dynamic. Dorsal blastomere expression turns off, leaving strong expression in head, ventral cord region, and tail at comma stage. As embryogenesis continues, expression fades in most cells so that by hatching, only ~12 cells positive for expression in head and ~6 cells in tail (all presumptive neurons). Post-embryonic staining unknown. | |||
| lacZ expression: 1 construct in 3 independant lines shows onset of expression in comma stage embryos in a few presumptive neuronal precursors in the head. In later stage embryos expression is in the head, ventral half and tail of embryos. This expression co-localizes with areas of neurogenesis. Post-embryonic expression in occasional neurons in head, tail, or midsection. | ||||
| Remark | Sequence Genbank accession numbers cDNA = U13614; genDNA = U30248 | |||
| Vertebrate Homologs: Human and mouse protein(s) E12/E47. Invertebrate Homologs: Drosophila protein "Daughterless". Vertebrate E12 acts with MyoD. | ||||
| early embryonic expression profile would be consistant with a role of CeE12/Da in dosage comp. analogous to Daughterless in Dros.mel. but not evidence for it. Later embryonic expression suggests CeE12/Da is important for neurogenesis, probably a pairing partner for the acheate-scute homologs in the worm. This would be similar function to its role in vertebrates and Dros.mel.. CeE12 does not appear to be in body wall muscle cells therefore not a pairing partner for CeMyoD; this result is in constrast to vertebrate functions. | ||||
| life_stage summary : postembryonic | ||||
| Reference | WBPaper00002826 | |||
| Transgene | WBTransgene00029643 | |||
| Antibody_info | WBAntibody00000147 |
