WormBase Tree Display for Expr_pattern: Expr3952
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| Expr3952 | Expression_of | Gene | WBGene00001130 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00001130 | |||
| Expression_data | Life_stage | WBls:0000024 | ||
| WBls:0000038 | ||||
| WBls:0000027 | ||||
| WBls:0000035 | ||||
| WBls:0000041 | ||||
| Anatomy_term | WBbt:0003681 | Certain | ||
| WBbt:0005733 | Certain | |||
| WBbt:0005772 | Partial | |||
| WBbt:0005828 | Certain | |||
| Type | Reporter_gene | |||
| Pattern | In larvae and adult hermaphrodites, the expression of a Pdyn-1 dyn-1::gfp reporter was observed in all previously described dyn-1-expressing tissues, including gonadal sheath cells. In embryos, many cell types express Pdyn-1 dyn-1::gfp, including known engulfing cells such as the hypodermal cells, intestinal precursor cells, and the entire pharyngeal primordium. | |||
| Picture | WBPicture0000009998 | |||
| Remark | Site of action: To determine whether DYN-1 activity is required in the engulfing cell or the dying cell for the removal of cell corpses, dyn-1 cDNA was expressed under the control of the engulfing cell-specific promoter Pced-1 or the dying cell-specific promoter Pegl-1 and authors examined the ability of these transgenes to promote engulfment. Pced-1 dyn-1::gfp rescued the Ced phenotype of dyn-1(n4039) to the same extent as Pdyn-1 dyn-1cDNA. In contrast, Pegl-1 dyn-1::gfp did not exhibit significant rescuing activity, although it produced a GFP signal in dying cells. These results indicate that the dyn-1 activity in engulfing cells, but not in dying cells, is sufficient for the rescue of the Ced phenotype. dyn-1 thus primarily functions in engulfing cells for the removal of apoptotic cells. | |||
| Reference | WBPaper00027659 | |||
| Transgene | WBTransgene00028991 |
