WormBase Tree Display for Expr_pattern: Expr2770
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| Expr2770 | Expression_of | Gene | WBGene00006791 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00006791 | |||
| Expression_data | Anatomy_term | WBbt:0003679 | Certain | |
| WBbt:0005319 | Certain | |||
| GO_term | GO:0008021 | |||
| Subcellular_localization | The kinesin motor protein, encoded by the unc-104 gene, is required for synaptic vesicle transport from the cell body to neuromuscular junctions. In unc-104 mutants, GFP-tagged endophilin accumulated in the cell bodies rather than at synapses. These data suggest that endophilin is a cargo of the synaptic vesicle kinesin. The simplest interpretation of this result is that endophilin is associated with synaptic vesicles. However, it is also possible that endophilin requires synaptic vesicle cycling at the synapse for proper localization and that endophilin mislocalization is an indirect consequence of synaptic vesicle mislocalization in the kinesin mutant. | |||
| Type | Reporter_gene | |||
| Pattern | GFP-tagged endophilin was enriched in puncta in all neuropil and colocalized with synaptobrevin, demon strating that endophilin is localized to synapses. In addition, weak protein expression was observed in the spermatheca. Furthermore, analysis of a genotype that mislocalizes synaptic vesicles suggests that endophilin may be associated with vesicles. | |||
| Picture | WBPicture0000009631 | |||
| Reference | WBPaper00006213 | |||
| Transgene | WBTransgene00001647 |
