WormBase Tree Display for Expr_pattern: Expr1601

Expr1601 Expression_of: Gene: WBGene00006776
    Reflects_endogenous_expression_of: WBGene00006776
  Homol: Homol_homol: T19B4:Expr
  Expression_data: Life_stage: WBls:0000022
      WBls:0000018
      WBls:0000019
      WBls:0000020
      WBls:0000017
      WBls:0000021
      WBls:0000010
    Anatomy_term (63)
    GO_term: GO:0005737
  Subcellular_localization: cytoplasmic expression
  Type: Reporter_gene
  Pattern: Expressed on the surface of motile cells and pioneering neurons whose migrations are affected in unc-40 mutants. UNC-40/GFP becomes detectable on the surface of all cells at the onset of gastrulation (~100 min after first cleavage), and then gradually decreases. By the end of gastrulation (~290 min), the protein is barely detectable on all cells. In the neurula (~400 min), UNC-40/GFP is highly expressed on ventral cord motorneurons, including cell bodies and axons, undergoing axonogenesis. Additional neurons express UNC-40/GFP soon after, but are difficult to identify in the elongating neurula. This expression generally persists into the first larval stage and beyond, allowing unambiguous identification of most cells. Similar expression patterns were observed using unc-40 upstream regulatory sequences to direct cytoplasmic expression of soluble GFP.
    In first stage larvae, ventral epidermoblasts P1/2 to P11/12 (Pn cells) express UNC-40/GFP as they undergo planar movements within the epithelium. Similarly, neuroblasts QL and QR and their descendants express UNC-40/GFP as they migrate longitudinally along the epidermis. In second stage and later larvae, the distal tip cells of hermaphrodites express UNC-40/GFP as they migrate along the body wall.
  Picture: WBPicture0000009499
    WBPicture0000009500
  Remark: Reporter gene fusion type not specified.
  Reference: WBPaper00002571
  Transgene: WBTransgene00027588