WormBase Tree Display for Expr_pattern: Expr15965
expand all nodes | collapse all nodes | view schema
| Expr15965 | Expression_of | Gene | WBGene00002299 | ||
|---|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00002299 | ||||
| Expression_data | Anatomy_term | WBbt:0003679 | Certain | ||
| WBbt:0004540 | Certain | ||||
| WBbt:0005739 | Certain | ||||
| Remark | Expressed in sensory tissue in the head. | ||||
| WBbt:0005829 | Certain | ||||
| WBbt:0006749 | Certain | ||||
| WBbt:0006750 | Certain | ||||
| Type | Genome_editing | ||||
| Reporter_gene | |||||
| Pattern | Endogenously tagged LIN-2, LIN-7, LIN-10 and LET-23 EGFRallow for the analysis of their localization and expression patterns in other tissues. We found that all four proteins are expressed inneurons and sensory tissue in the head, and along the ventral anddorsal nerve chords. The intestine is prone to a highdegree of autofluorescence and was excluded from the initialanalysis. Whereas LET-23 EGFR and LIN-7 overlapped minimallyin the head, LIN-2 and LIN-7 colocalized strongly in theneural ring, and the ventral and dorsal nerve chords. Ofnote, we observed that LIN-2 was more strongly expressed in theisthmus of the pharynx than LIN-7. In contrast, LIN-7 wasmore strongly expressed in the gonad and uterus than LIN-2. LIN-10 overlapped minimally with LIN-2 in the neural ring and nerve chords, and shared very little overlap with LET-23 EGFR in other neural tissues in the head of the worm. LET-23::mK2 was strongly expressed in the excretory duct cell in which it signals through the LET-60 Ras/MPK-1 ERK pathway to regulate excretory duct cell development (Abdus-Saboor et al., 2011; Yochem et al., 1997). | ||||
| Reference | WBPaper00060988 | ||||
| Variation | WBVar02157233 |
