WormBase Tree Display for Expr_pattern: Expr1589
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| Expr1589 | Expression_of | Gene | WBGene00001179 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00001179 | |||
| Expression_data | Life_stage | WBls:0000002 | ||
| Anatomy_term | WBbt:0003679 | Certain | ||
| WBbt:0005813 | Certain | |||
| GO_term | GO:0043005 | |||
| Subcellular_localization | The stained structures consisted of bundles of neural processes and were at the locations of the majority of the chemical synapses in the animal. In neurons, EGL-10 protein appeared to be localized exclusively to processes; no staining was seen in the neural cell bodies of wild-type animals. Animals at all stages of development from first stage larvae to adults showed similar staining of neural processes. | |||
| Type | Antibody | affinity-purified anti-EGL-10 antibodies. | ||
| Pattern | In worms that overexpress EGL-10 from a multicopy array of egl-10 transgenes, EGL-10 was detected in neural cell bodies as well as neural processes of these animals, either because overexpression raised the level of EGL-10 protein in cell bodies above the threshold of detection or because overexpression of EGL-10 exceeded the capacity of neurons to localize the protein to processes. A large number of neurons in the major ganglia of the head region expressed EGL-10. In addition, examination of the ventral cord neurons, lateral neurons, and tail ganglia suggested that most if not all neurons in C. elegans expressed EGL-10. In particular, the HSN motor neurons, expressed EGL-10. | |||
| Staining observed in the nerve ring, ventral nerve cord, and dorsal nerve cord of wild-type animals. | ||||
| Picture | WBPicture0000009491 | |||
| Remark | Body wall muscles were also stained. The staining did not disappear in egl-10 null animals but it was strengthened in egl-10 overexpression lines. | |||
| Reference | WBPaper00002370 | |||
| Antibody_info | WBAntibody00000103 |
