WormBase Tree Display for Variation: WBVar02148895

WBVar02148895 Evidence: Paper_evidence: WBPaper00053300
  Name: Public_name: jy1
    Other_name: C29F9.1.1:c.151C>T
      CE08449:p.Arg51Ter
    HGVSg: CHROMOSOME_III:g.132575C>T
  Sequence_details: SMap: S_parent: Sequence: C29F9
    Flanking_sequences: gggattcatgctcaagcgggatgtgcgact gacctatcagtgctcatatcgtgcctcaa
    Mapping_target: C29F9
    Type_of_mutation: Substitution: C T Person_evidence: WBPerson3965
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00007237
      WBStrain00056787
      WBStrain00056788
      WBStrain00056790
    Laboratory: ERT
    Status: Live
  Affects: Gene: WBGene00016216
    Transcript: C29F9.1.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: C29F9.1.1:c.151C>T
        HGVSp: CE08449:p.Arg51Ter
        cDNA_position: 158
        CDS_position: 151
        Protein_position: 51
        Exon_number: 2/6
        Codon_change: Cga/Tga
        Amino_acid_change: R/*
    Interactor: WBInteraction000561571
      WBInteraction000583597
      WBInteraction000583598
      WBInteraction000583600
      WBInteraction000583601
      WBInteraction000583605
      WBInteraction000583606
  Isolation: Mutagen: EMS
    Forward_genetics: Screen for constitutive pals-5::GFP expression
  Genetics: Interpolated_map_position: III -26.9838
  Description: Phenotype: WBPhenotype:0000295 Paper_evidence: WBPaper00053300
          WBPaper00059442
        Curator_confirmed: WBPerson3965
        Remark: (Fig. 1B) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
        Phenotype_assay: Strain: WBStrain00049931 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
      WBPhenotype:0000848 Paper_evidence: WBPaper00059442
        Curator_confirmed: WBPerson3965
        Remark: The pals-22(jy1) mutation causes developmental delay (Fig. S7) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
          The rcs-1(jy84) mutation does not affect the developmental delay of pals-22(jy1) mutants (Fig. S7) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
          The skr-3(ok365);skr-5(ok3068) double mutant does not affect the developmental delay of pals-22(jy1) mutants (Fig. S7) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
          The skr-3(ok365);skr-4(gk759439) double mutant does not affect the developmental delay of pals-22(jy1) mutants (Fig. S7) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
          The skr-5(ok3068);skr-4(gk759439) double mutant does not affect the developmental delay of pals-22(jy1) mutants (Fig. S7) Paper_evidence: WBPaper00059442
            Curator_confirmed: WBPerson3965
        Phenotype_assay: Strain: WBStrain00049931 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052718 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052719 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052721 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052724 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
          Control_strain: WBStrain00049931 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052720 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052722 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            WBStrain00052723 Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
          Genotype: rcs-1(jy84) X Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            skr-3(ok365) skr-5(ok3068) V Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            skr-3(ok365) skr-4(gk759439) V Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
            skr-5(ok3068) skr-4(gk759439) V Paper_evidence: WBPaper00059442
              Curator_confirmed: WBPerson3965
      WBPhenotype:0001014 Paper_evidence: WBPaper00056034
        Curator_confirmed: WBPerson3965
        Remark: pals-22(jy1) confers an increased resistance to intracellular pathogens Paper_evidence: WBPaper00056034
            Curator_confirmed: WBPerson3965
        EQ_annotations: GO_term: GO:0098542 PATO:0000460 Paper_evidence: WBPaper00056034
                Curator_confirmed: WBPerson3965
      WBPhenotype:0002474 Paper_evidence: WBPaper00061877
        Curator_confirmed: WBPerson23334
    Phenotype_not_observed: WBPhenotype:0002252 Paper_evidence: WBPaper00061877
        Curator_confirmed: WBPerson23334
  Reference: WBPaper00053300
    WBPaper00056034
    WBPaper00061877
    WBPaper00065984
    WBPaper00059442
  Remark: Created in the nameserver by Chris Grove
    WBPaper00053300, allele of pals-22
    amino acid 51: CGA (R) to TGA (stop)
    [200207 gw3] Corrected flanking sequences
    Manually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00016216 Opal_UGA
  Method: Substitution_allele