WormBase Tree Display for Variation: WBVar02125412

WBVar02125412 Name: Public_name: ok3351
    Other_name: W07E11.3b.1:c.-6_182+91del
      W07E11.3a.1:c.-6_275+91del
      W07E11.1b.1:c.1225-744_1225-373del
      W07E11.1a.1:c.1225-744_1225-373del
    HGVSg: CHROMOSOME_X:g.10094790_10095161del
  Sequence_details: SMap: S_parent: Sequence: W07E11
    Flanking_sequences: ttccaaatatgtgtttgggttttaagcttg cgacaattggtttggcaacgactgacaatg
    Mapping_target: W07E11
    Type_of_mutation: Deletion
    PCR_product: OK3351_external
      OK3351_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00037433
      WBStrain00047161
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00001445
      WBGene00012326
    Transcript: W07E11.1a.1 VEP_consequence: intron_variant
        VEP_impact: MODIFIER
        HGVSc: W07E11.1a.1:c.1225-744_1225-373del
        Intron_number: 5/19
      W07E11.3b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: W07E11.3b.1:c.-6_182+91del
        cDNA_position: 85-?
        Intron_number: 2-3/4
        Exon_number: 1-3/5
      W07E11.1b.1 VEP_consequence: intron_variant
        VEP_impact: MODIFIER
        HGVSc: W07E11.1b.1:c.1225-744_1225-373del
        Intron_number: 5/20
      W07E11.3a.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: W07E11.3a.1:c.-6_275+91del
        cDNA_position: 64-?
        Intron_number: 2/3
        Exon_number: 1-2/4
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000130 Paper_evidence: WBPaper00053388
        Curator_confirmed: WBPerson46589
        Remark: Figure 5C, Increased dauer entry in flp mutants Paper_evidence: WBPaper00053388
            Curator_confirmed: WBPerson46589
        Phenotype_assay: Strain: WBStrain00047161 Paper_evidence: WBPaper00053388
              Curator_confirmed: WBPerson46589
          Control_strain: WBStrain00000001 Paper_evidence: WBPaper00053388
              Curator_confirmed: WBPerson46589
          Treatment: Animals were exposed to crude pheremone to induce entry into the dauer larva state Paper_evidence: WBPaper00053388
              Curator_confirmed: WBPerson46589
    Phenotype_not_observed: WBPhenotype:0000039 Paper_evidence: WBPaper00065376
        Curator_confirmed: WBPerson712
        Remark: 21 days vs N2 21 days (n=120) Paper_evidence: WBPaper00065376
            Curator_confirmed: WBPerson712
      WBPhenotype:0000067 Paper_evidence: WBPaper00065376
        Curator_confirmed: WBPerson712
        Remark: "Although flp-2 null mutants showed a normal lifespan, they exhibited decreased survivability in the thermal assay, in both young adults and older adults (Day-5 adult stage). In contrast, flp-2 mutants displayed normal tolerance to paraquat." Paper_evidence: WBPaper00065376
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 35 Paper_evidence: WBPaper00065376
              Curator_confirmed: WBPerson712
      WBPhenotype:0000460 Paper_evidence: WBPaper00065376
        Curator_confirmed: WBPerson712
        Remark: "Although flp-2 null mutants showed a normal lifespan, they exhibited decreased survivability in the thermal assay, in both young adults and older adults (Day-5 adult stage). In contrast, flp-2 mutants displayed normal tolerance to paraquat." Paper_evidence: WBPaper00065376
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00065376
              Curator_confirmed: WBPerson712
  Reference: WBPaper00053388
    WBPaper00065376
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele