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WormBase Tree Display for Variation: WBVar00600740

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Name Class

WBVar00600740EvidencePaper_evidenceWBPaper00040149
NamePublic_nameu332
Other_nameF16F9.5.1:c.2039G>A
CE09444:p.Gly680Glu
HGVSgCHROMOSOME_X:g.8466142C>T
Sequence_detailsSMapS_parentSequenceF16F9
Flanking_sequencesaaatgatggctgattttggaggacaccttgactttggtcaggagtttctgttatgacttg
Mapping_targetF16F9
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00040149
SeqStatusNot_sequenced
Deletion_verification
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryTU
StatusLive
AffectsGeneWBGene00003174
TranscriptF16F9.5.1 (12)
GeneticsInterpolated_map_positionX0.00712395
DescriptionPhenotypeWBPhenotype:0000456Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
RemarkOn average, mec-10 mutant animals respond only to 1-4 touches of 10, whereas wild-type animals respond to 9 touches of 10.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
WBPhenotype:0002028Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
RemarkMutants have MRCs with a dramatic reduction in peak MRC size compared to wild-type. Touch receptor neuron respond to applied pressure stimulus. Latency for MRC off response are extended compared to wild type. Mutations in MEC-10 shifted the reversal potential for MRCs by -40 mV or more.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005490PATO:0000460Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000436Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
RemarkThe distribution of the mechanoreceptor channels along the process of PLM touch receptor neurons is essentially unchanged in mec-10 mutants as assayed by the localization pattern of MEC-4::YFP and anti-MEC-2 antibody staining.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
ReferenceWBPaper00040149
MethodSubstitution_allele