WormBase Tree Display for Variation: WBVar00275404

WBVar00275404 Evidence: Paper_evidence: WBPaper00035074
  Name: Public_name: ye494
    Other_name: CE36501:p.Ser261Leu
      T07A5.2.1:c.782C>T
    HGVSg: CHROMOSOME_III:g.10315013G>A
  Sequence_details: SMap: S_parent: Sequence: T07A5
    Flanking_sequences: cacaaaactcaatacttcctctatcccatct gttcattttcatgttctttgtggcgacactg
    Mapping_target: T07A5
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00035074
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: HY
    Status: Live
  Affects: Gene: WBGene00006785
    Transcript: T07A5.2.1 VEP_consequence: missense_variant
        VEP_impact: MODERATE
        HGVSc: T07A5.2.1:c.782C>T
        HGVSp: CE36501:p.Ser261Leu
        cDNA_position: 814
        CDS_position: 782
        Protein_position: 261
        Exon_number: 5/6
        Codon_change: tCg/tTg
        Amino_acid_change: S/L
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: III 2.30734
  Description: Phenotype: WBPhenotype:0000421 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: trb mutants are qualitatively and quantitatively resistant to levamisole Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00035074
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001578 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: trb mutants are qualitatively and quantitatively resistant to pyrantel (L-subtype nAChR agonist) Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001852 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: All trb mutants are clearly resistant to tribendimidine-induced mortality and tribendimidine-induced sterility Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00035074
  Method: Substitution_allele