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WormBase Tree Display for Variation: WBVar00274918

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Name Class

WBVar00274918EvidencePaper_evidenceWBPaper00031828
NamePublic_nameur280
Other_nameCE47844:p.Lys369Asn
T25E12.10.1:c.1107T>C
HGVSgCHROMOSOME_V:g.16733943A>G
Sequence_detailsSMapS_parentSequenceT25E12
Flanking_sequencesAATCGACTTCAAAAATCAATAGCCCGTTTGCATAAAAAGAACTCCTGAACTTACAGTTCATTGTATACCAATCGCCATCATAAGGACCTCCACGTGCAAC
Mapping_targetT25E12
Type_of_mutationSubstitutiontgPaper_evidenceWBPaper00031828
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryIM
StatusLive
AffectsGeneWBGene00012025
TranscriptT25E12.10.1 (11)
Interactor (19)
GeneticsInterpolated_map_positionV11.1306
DescriptionPhenotypeWBPhenotype:0000961Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
RemarkIn 86% of clec-38 mutants, the distribution of SNB-1::GFP puncta is irregular, leaving clear areas in the dorsal and ventral cord. The number of dorsal and ventral cord puncta is reduced in clec-38 mutants. In addition, the remaining puncta are of irregular shape and size.Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005270PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBbt:0005303PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBPhenotype:0001236Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
RemarkUNC-40::GFP expression is increased.Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
WBPhenotype:0001685Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
RemarkIn 86% of clec-38 mutants, the distribution of SNB-1::GFP puncta is irregular, leaving clear areas in the dorsal and ventral cord. The number of dorsal and ventral cord puncta is reduced in clec-38 mutants. In addition, the remaining puncta are of irregular shape and size.Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005270PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBbt:0005303PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000180Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
RemarkAxons were not mispositioned.Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005270PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBbt:0005303PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBPhenotype:0000384Paper_evidenceWBPaper00035146
WBPaper00031828
Curator_confirmedWBPerson712
RemarkThe HSN axon migration pattern is no different from that observed in wild type animals.Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
Animals do not exhibit dorsal or ventral guidance defects.Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
WBbt:0005278PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBbt:0005274PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBbt:0005406PATO:0000460Paper_evidenceWBPaper00031828
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
RemarkUNC-40::GFP is ventrally localized as in wild type animals.Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
UNC-40::GFP is more ventrally localized as in wild type animals.Paper_evidenceWBPaper00035146
Curator_confirmedWBPerson712
ReferenceWBPaper00031828
WBPaper00035146
MethodSubstitution_allele