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WormBase Tree Display for Variation: WBVar00250956

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Name Class

WBVar00250956NamePublic_nametm1996
HGVSgCHROMOSOME_III:g.6912039_6912626del
Sequence_detailsSMapS_parentSequenceT07E3
Flanking_sequencestgagaaatctaactttcttggacggtcaagttggccatgaacttatcaattttcaatcga
Mapping_targetT07E3
Source_location7CHROMOSOME_III69120386912627Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationDeletion
PCR_producttm1996_external
tm1996_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026308
WBStrain00026321
WBStrain00031072
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq1996
NBP_allele
StatusLive
AffectsGeneWBGene00020317
TranscriptT07E3.6a.2VEP_consequencesplice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number2/4
Exon_number1-2/5
T07E3.6b.1VEP_consequencesplice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number2/5
Exon_number1-2/6
T07E3.6a.1VEP_consequencesplice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number2/5
Exon_number1-2/6
InteractorWBInteraction000519222
IsolationMutagenTMP/UV
GeneticsMapIII
DescriptionPhenotypeWBPhenotype:0000067Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
Remarkpdf-1 null mutants "...showed a decreased survivability against thermal stress at 5-day-old adult stage (Figure 1E and 1F)."Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive35Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
WBPhenotype:0000888Paper_evidenceWBPaper00048673
Curator_confirmedWBPerson2817
Remarkpdf-1 (tm1996) defective in male-specific sexual conditioningPaper_evidenceWBPaper00048673
Curator_confirmedWBPerson2817
WBPhenotype:0001506Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
RemarkAnimals exhibit a 3-fold increase in reversal frequency compared with N2.Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
WBPhenotype:0001713Paper_evidenceWBPaper00047014
Curator_confirmedWBPerson30438
Remarkpdf-1 mutant did not show diurnal or circadian rhythms under LD or DD conditions, respectively (Fig. 1b)Paper_evidenceWBPaper00047014
Curator_confirmedWBPerson30438
Phenotype_assayControl_strainWBStrain00000001Paper_evidenceWBPaper00047014
Curator_confirmedWBPerson30438
WBPhenotype:0001715Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
RemarkAnimals displayed an increase in the frequency of directional changes compared with N2.Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
WBPhenotype:0001717Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
RemarkAnimals displayed a significant decrease in centroid velocity compared with N2 animals. Animals exhibited movements that were ~50% slower than N2.Paper_evidenceWBPaper00031656
Curator_confirmedWBPerson712
WBPhenotype:0002128Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
RemarkMutant males remain on food in the absence of mates. Males had no drive to explore away from food.Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006814PATO:0000460Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
WBPhenotype:0002130Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
WBPhenotype:0002317Paper_evidenceWBPaper00044094
Curator_confirmedWBPerson23309
WBPhenotype:0004004Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
RemarkMutants were able to successfully mate, although they did not respond as avidly as wild-type males to mate contact.Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
RemarkIn agreement with the flp-2 null mutant results, pdf-1 null mutants also exhibited a normal lifespan (Figure 1A and 1B), and stress tolerance against paraquat (Figure 1C and 1D).Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
WBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of Japan. Comment to the NBP from Dr. S. Husson: J. Biol. Chem. 283, 15241 (2008).Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceFX
WBPhenotype:0000460Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
RemarkIn agreement with the flp-2 null mutant results, pdf-1 null mutants also exhibited a normal lifespan (Figure 1A and 1B), and stress tolerance against paraquat (Figure 1C and 1D).Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002747Paper_evidenceWBPaper00065376
Curator_confirmedWBPerson712
ReferenceWBPaper00041718
WBPaper00031656
WBPaper00044094
WBPaper00047014
WBPaper00048673
WBPaper00065376
Remark14212/14213-14800/14801 (588 bp deletion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele