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WormBase Tree Display for Variation: WBVar00250403

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Name Class

WBVar00250403NamePublic_nametm1410
Other_nameCE28488:p.His62LeufsTer9
T23F2.1b.1:c.227_765delinsTTT
T23F2.1a.1:c.185_723delinsTTT
CE54583:p.His76LeufsTer9
HGVSgCHROMOSOME_X:g.5493996_5494701delinsTTT
Sequence_detailsSMapS_parentSequenceT23F2
Flanking_sequencescagaaattcgagaggttgggctcaagcttcatgccacacattccggaaagtagaatatat
Mapping_targetT23F2
Source_location7CHROMOSOME_X54939955494702Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationInsertionTTT
Deletion
PCR_producttm1410_external
tm1410_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004737
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq1410
NBP_allele
StatusLive
AffectsGeneWBGene00044623
TranscriptT23F2.1b.1 (11)
T23F2.1a.1 (11)
IsolationMutagenTMP/UV
GeneticsMapX
DescriptionPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Remark100% embryonic lethal. 55% of the embryos arrested with an enlarged, deep and persistent gastrulation cleft, ventral enclosure was not completed; 12% of the embryos arrested with completed ventral enclosure at the posterior of the embryo, but not at the anterior; the remaining 33% of the embryos arrested after an apparently normal ventral enclosure but experience slow leakage of cells from the anterior tip of the animal.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_assayGenotypejcIs1Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
WBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as lethal OR sterile by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceFX
WBPhenotype:0000688Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as lethal OR sterile by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceFX
WBPhenotype:0001566Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Remark100% embryonic lethal. 55% of the embryos arrested with an enlarged, deep and persistent gastrulation cleft, ventral enclosure was not completed; 12% of the embryos arrested with completed ventral enclosure at the posterior of the embryo, but not at the anterior; the remaining 33% of the embryos arrested after an apparently normal ventral enclosure but experience slow leakage of cells from the anterior tip of the animal.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_assayGenotypejcIs1Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
ReferenceWBPaper00031667
Remark1727/1728-TTT-2433/2434 (706 bp deletion + 3 bp insertion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele