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WormBase Tree Display for Variation: WBVar00250150

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Name Class

WBVar00250150NamePublic_nametm1133
Other_nameCE02898:p.Glu62_Ile167delinsGlnCysGlyTer
ZK1248.14.1:c.184_500delinsCAATGTGGCTGAAC
HGVSgCHROMOSOME_II:g.5835553_5835971delinsGTTCAGCCACATTG
Sequence_detailsSMapS_parentSequenceZK1248
Flanking_sequencestctgaattttcgtcactcagtgcgtgtccatagttcagccacattgtctttcagttctcc
Mapping_targetZK1248
Source_location7CHROMOSOME_II58355525835972Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationInsertionGTTCAGCCACATTG
Deletion
PCR_producttm1133_external
tm1133_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005194
WBStrain00056745
Component_of_genotypeWBGenotype00000133
WBGenotype00000135
LaboratoryFX
EN
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq1133
NBP_allele
StatusLive
AffectsGeneWBGene00001509
TranscriptZK1248.14.1 (11)
InteractorWBInteraction000571765
WBInteraction000571767
WBInteraction000571768
IsolationMutagenTMP/UV
GeneticsMapII
DescriptionPhenotypeWBPhenotype:0000031Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. J-C. Martinou to the National Bioresource Project of : a bit slow growth at 20 degree.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceJCM
Phenotype_assayTemperature20Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000059Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
RemarkTransient phenotype, depends on the mitochondrial DNA deletion copy numbers.Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
WBPhenotype:0000120Paper_evidenceWBPaper00035144
Curator_confirmedWBPerson712
RemarkThe level of bc1 protein (a protein of complex III of the electron transport chain) is reduced in fzo-1(tm1133) animalsPaper_evidenceWBPaper00035144
Curator_confirmedWBPerson712
WBPhenotype:0000140Paper_evidenceWBPaper00041209
Curator_confirmedWBPerson712
Remarkexacerbated L3 arrest compared with wild-type at 72 and 96 hPaper_evidenceWBPaper00041209
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003513Paper_evidenceWBPaper00041209
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000035PATO:0000460Paper_evidenceWBPaper00041209
Curator_confirmedWBPerson712
Phenotype_assayTreatmentserial ultraviolet C radiation(UVC) exposure (10 J/m2)Paper_evidenceWBPaper00041209
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
RemarkAggravated phenotype depends on the mitochondrial DNA deletion copy numbers.Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
WBPhenotype:0000273Paper_evidenceWBPaper00056369
Curator_confirmedWBPerson9270
WBPhenotype:0001282Paper_evidenceWBPaper00035144
WBPaper00047030
Curator_confirmedWBPerson712
WBPerson25433
Remarkfzo-1(tm1133) animals seem to have less active mitochondria when stained with TMREPaper_evidenceWBPaper00035144
Curator_confirmedWBPerson712
Reduced maximal respiratory capacity, spare respiratory capacity, and proton leak in L4 stage nematodesPaper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
EQ_annotationsLife_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
GO_termGO:0009060PATO:0000460Paper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
GO:0005739PATO:0000460Paper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
WBPhenotype:0001401Paper_evidenceWBPaper00047030
WBPaper00059575
Curator_confirmedWBPerson25433
WBPerson557
RemarkFragmented mitochondria in L4 stage nematodesPaper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
fzo-1(tm1133) animals have small spherical mitochondria.Paper_evidenceWBPaper00059575
Curator_confirmedWBPerson557
EQ_annotationsLife_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
GO_termGO:0005739PATO:0001444Paper_evidenceWBPaper00047030
Curator_confirmedWBPerson25433
Phenotype_assayTemperature20Paper_evidenceWBPaper00059575
Curator_confirmedWBPerson557
WBPhenotype:0001805Paper_evidenceWBPaper00032231
WBPaper00033026
Curator_confirmedWBPerson712
RemarkMitochondria were vesiculated.Paper_evidenceWBPaper00032231
Curator_confirmedWBPerson712
fzo-1(tm1133) embryos displayed only small and spherical mitochondria, with a mean mitochondrial length of 0.38 umPaper_evidenceWBPaper00033026
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00032231
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00033026
Curator_confirmedWBPerson712
GO_termGO:0005739PATO:0000460Paper_evidenceWBPaper00032231
Curator_confirmedWBPerson712
WBPhenotype:0002430Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
RemarkSelection against mitochondrial DNA harboring deletions including uaDf5, bguDf1, bguDf2.Paper_evidenceWBPaper00062487
Curator_confirmedWBPerson5063
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of Japan. Comments to the NBP from Dr. Xue: Mol Cell 31, 586 (2008). Dr. T. Oka: J. Biochem. 143, 449 (2008).Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceFX
CU
WBPhenotype:0000746Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment to the National Bioresource Project of Japan: Dr. H. Sawa: normal embryonic cell division.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceHS
WBPhenotype:0001380Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. J-C. Martinou to the National Bioresource Project of : not hypersensitive to anoxia.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceJCM
Reference (11)
Remark26031/26032-GTTCAGCCACATTG-26450/26451 (419 bp deletion + 14 bp insertion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele