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WormBase Tree Display for Variation: WBVar00248855

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Name Class

WBVar00248855EvidencePaper_evidenceWBPaper00005824
NamePublic_namesu158
Other_nameCE20549:p.Ile31ThrfsTer46
C38C3.5.1:c.92_290del
HGVSgCHROMOSOME_V:g.1477340_1478037del
Sequence_detailsSMapS_parentSequenceC38C3
Flanking_sequencescgaaaaaaaataaatcaaaaaataatcagagtgagtttcaacattgaaatattacacata
Mapping_targetC38C3
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00029953
LaboratoryHE
StatusLive
AffectsGeneWBGene00006794
TranscriptC38C3.5.1 (11)
InteractorWBInteraction000520189
GeneticsInterpolated_map_positionV-18.8758
DescriptionPhenotypeWBPhenotype:0000643Paper_evidenceWBPaper00005824
Curator_confirmedWBPerson48
Remarkshows a more severe motility defect than a strong loss-of-function mutant e677Paper_evidenceWBPaper00005824
Curator_confirmedWBPerson48
WBPhenotype:0001213Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
RemarkAnimals were nearly paralyzed. Motility (organization) was rescued by GFP-UNC-60B(WT) and largely by GFP-UNC-60B(deletion 152), but not by GFP-UNC-60B(deletion 150).Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006804PATO:0000460Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0001570Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
RemarkAnimals had disorganized actin filaments with large aggregates in the body-wall muscle, demonstrated by tetramethylrhodamine-phalloidin staining of F-actin. Actin striation (organization) was rescued by GFP-UNC-60B(WT) but not by GFP-UNC-60B(deletion 150) and only partially by GFP-UNC-60B(deletion 152).Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006804PATO:0000460Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0001587Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
RemarkHomozygotes had severely disorganized actin filaments with formation of actin aggregates in the body wall muscle.Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006804PATO:0000460Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
Life_stageWBls:0000023PATO:0000460Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
WBls:0000041PATO:0000460Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
WBls:0000003PATO:0000460Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
GO_termGO:0005884PATO:0000937Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
WBPhenotype:0001930Paper_evidenceWBPaper00032907
Curator_confirmedWBPerson712
RemarkAnimals were isolated based on altered or fewer muscle arms, observed by an altered pattern of trIs25 reporter expression, which expresses membrane-anchored YFP in select muscles of only the distal row of body wall muscles.Paper_evidenceWBPaper00032907
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Paper_evidenceWBPaper00005824
Curator_confirmedWBPerson48
Variation_effectNullPaper_evidenceWBPaper00005824
Curator_confirmedWBPerson48
WBPhenotype:0000436Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
RemarkCAS-1 subcellular localization was not disturbed in the unc-60B-null mutant. CAS-1 remained associated with striated myofibrils.Paper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00041203
Curator_confirmedWBPerson712
WBPhenotype:0000666Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0000668Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
RemarkNo endomitotic oocytes were detected in the proximal gonad (n=50).Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0001354Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
RemarkActin filaments were nearly normally organized into a non-striated meshwork in the myoepithelial-sheath cells. As by tetramethylrhodamine-phalloidin staining of F-actin.Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005828PATO:0000460Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0001587Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
RemarkThere was no major difference in actin organization in the myoepithelial sheath cells compared to wild type animals, as assayed by tetramethylrhodamine-phalloidin staining of F-actin.Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005828PATO:0000460Paper_evidenceWBPaper00032057
Curator_confirmedWBPerson712
WBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
ReferenceWBPaper00041203
WBPaper00032446
WBPaper00032907
WBPaper00005824
WBPaper00032057
RemarkFlanking sequences are 30 bp to the left of the start of 3B and 30 bp to the right of the end of 4B as no precise coordinates are specified in paperCurator_confirmedWBPerson1845
su158 is a null of unc-60B and has a deletion of 600 bp that completely removes exons 3B and 4B and does not disturb the unc-60A regionPaper_evidenceWBPaper00005824
MethodDeletion_allele