WormBase Tree Display for Variation: WBVar00242670

WBVar00242670 Name: Public_name: sc8
    Other_name: F23H12.4b.1:c.674G>A
      CE05707:p.Gly291Glu
      F23H12.4a.1:c.872G>A
      CE46560:p.Gly225Glu
    HGVSg: CHROMOSOME_V:g.12354046G>A
  Sequence_details: SMap: S_parent: Sequence: F23H12
    Flanking_sequences: tgtaatatttcaggtattgcgctctcgatg aggagtcttcttcgaggacggaaccagacg
    Mapping_target: F23H12
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024637
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00000253
      WBStrain00003786
      WBStrain00005521
      WBStrain00008019
      WBStrain00022738
      WBStrain00022749
      WBStrain00023555
      WBStrain00027209
      WBStrain00029194
    Laboratory: BE
    Status: Live
  Affects: Gene: WBGene00005018
    Transcript: F23H12.4a.1 (12)
      F23H12.4b.1 (12)
    Interactor: WBInteraction000052482
      WBInteraction000052494
      WBInteraction000052498
      WBInteraction000052512
      WBInteraction000052514
      WBInteraction000052519
      WBInteraction000052543
      WBInteraction000052552
      WBInteraction000519640
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00024637
  Genetics: Interpolated_map_position: V 4.00901
    Mapping_data: In_2_point: 255
        305
        849
        850
        851
        3129
      In_multi_point (25)
      In_pos_neg_data: 1758
  Description: Phenotype: WBPhenotype:0000501 Paper_evidence: WBPaper00000465
          WBPaper00000906
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Also, weak roller in Dauer stage. Paper_evidence: WBPaper00000465
            Curator_confirmed: WBPerson712
          adults and L4 larvae left-handed rollers, easy to score (ES3) in adult Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000465
            WBPaper00000906
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000038 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
            20C, 25C Paper_evidence: WBPaper00000906
              Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000583 Paper_evidence: WBPaper00000906
        Curator_confirmed: WBPerson712
        Remark: Weak dumpy as transheterozygote with e24 at 25C not 20C. Paper_evidence: WBPaper00000906
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000906
              Curator_confirmed: WBPerson712
      WBPhenotype:0001516 Paper_evidence: WBPaper00000465
        Curator_confirmed: WBPerson712
        Remark: Alae make 1/2 turn along the length of the animal. Paper_evidence: WBPaper00000465
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000465
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
      WBPhenotype:0001517 Paper_evidence: WBPaper00000465
        Curator_confirmed: WBPerson712
        Remark: Annulae slightly deranged. Paper_evidence: WBPaper00000465
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000465
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25 Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000505 Paper_evidence: WBPaper00001328
        Curator_confirmed: WBPerson712
        Remark: Males are not Ram. Paper_evidence: WBPaper00001328
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006941 PATO:0000460 Paper_evidence: WBPaper00001328
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001328
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00001328
              Curator_confirmed: WBPerson712
          Genotype: him-5(e1490) Paper_evidence: WBPaper00001328
              Curator_confirmed: WBPerson712
      WBPhenotype:0000583 Paper_evidence: WBPaper00000465
        Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000465
          Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
      WBPhenotype:0001412 Paper_evidence: WBPaper00000465
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
      WBPhenotype:0001515 Paper_evidence: WBPaper00000465
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000465
                Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00000465
              Curator_confirmed: WBPerson712
      WBPhenotype:0001687 Paper_evidence: WBPaper00001280
        Curator_confirmed: WBPerson712
        Remark: Animals did not show any level of immunofluorescence significantly higher than wild-type controls. Paper_evidence: WBPaper00001280
            Curator_confirmed: WBPerson712
  Reference: WBPaper00001328
    WBPaper00000465
    WBPaper00013885
    WBPaper00001280
    WBPaper00000906
  Method: Substitution_allele