WormBase Tree Display for Variation: WBVar00242520

WBVar00242520 Evidence: Paper_evidence: WBPaper00002315
  Name: Public_name: sa201
    Other_name: F09B12.6.1:c.742G>A
      CE26710:p.Gly248Arg
    HGVSg: CHROMOSOME_X:g.15091568G>A
  Sequence_details: SMap: S_parent: Sequence: F09B12
    Flanking_sequences: attaacgaagttatctattttagggctctg gatgtacgttcattgaaatgttattaaaac
    Mapping_target: F09B12
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: JT
    Status: Live
  Affects: Gene: WBGene00001468
    Transcript: F09B12.6.1 (12)
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: X 21.8364
    Mapping_data: In_multi_point: 3258
        3259
  Description: Phenotype: WBPhenotype:0000031 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow growing Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000209 Paper_evidence: WBPaper00002315
        Person_evidence: WBPerson309
          WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: Animals exhibited very short defecation cycles, which were significantly shorter at 25C. Paper_evidence: WBPaper00002315
            Curator_confirmed: WBPerson712
          ts, at 25C very short defecation cycle period, often with weak or missing motor program steps Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Person_evidence: WBPerson309
              Curator_confirmed: WBPerson48
        Recessive: Paper_evidence: WBPaper00002315
          Person_evidence: WBPerson309
          Curator_confirmed: WBPerson48
            WBPerson712
        Variation_effect: Hypomorph_reduction_of_function: Person_evidence: WBPerson309
            Curator_confirmed: WBPerson48
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00002315
              Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25 Person_evidence: WBPerson309
              Curator_confirmed: WBPerson48
            20, 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
      WBPhenotype:0000314 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000380 Paper_evidence: WBPaper00002315
        Curator_confirmed: WBPerson712
        Remark: The Exp step was activated less frequently, corresponding to shorter cycle periods. Paper_evidence: WBPaper00002315
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00002315
          Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20, 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
      WBPhenotype:0000651 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Con Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001502 Person_evidence: WBPerson309
        Curator_confirmed: WBPerson48
        Remark: Resistant to 0.4 mg/ml NaF Person_evidence: WBPerson309
            Curator_confirmed: WBPerson48
        Penetrance: Incomplete: Person_evidence: WBPerson309
              Curator_confirmed: WBPerson48
        Phenotype_assay: Temperature: 25 Person_evidence: WBPerson309
              Curator_confirmed: WBPerson48
      WBPhenotype:0001641 Paper_evidence: WBPaper00002315
        Curator_confirmed: WBPerson712
        Remark: pBocs were noticibly weaker with the shortened cycle periods. Paper_evidence: WBPaper00002315
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00002315
          Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20, 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
      WBPhenotype:0001791 Paper_evidence: WBPaper00002315
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited significantly different defecation cycles at 20C from that at 25C. Paper_evidence: WBPaper00002315
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00002315
          Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20, 25 Paper_evidence: WBPaper00002315
              Curator_confirmed: WBPerson712
      WBPhenotype:0001855 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: fluoride resistant Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003913 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000659 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: appears to feed normally Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
  Reference: WBPaper00002315
  Method: Substitution_allele