WormBase Tree Display for Variation: WBVar00241119

WBVar00241119 Evidence: Paper_evidence: WBPaper00013460
  Name: Public_name: q465
    HGVSg: CHROMOSOME_II:g.10870768_10872007del
  Sequence_details: SMap: S_parent: Sequence: CHROMOSOME_II
    Flanking_sequences: gatataattgatcttcaagacccaaatcat gaaatgaaaagtaatcttaaagaggataat
    Mapping_target: CHROMOSOME_II
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00022548
    Laboratory: JK
    Status: Live
  Affects: Gene: WBGene00000293
      WBGene00000880
    Transcript: F59E10.2.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: 504-?
        CDS_position: 499-?
        Protein_position: 167-?
        Intron_number: 4-5/6
        Exon_number: 4-7/7
      M106.5.1 VEP_consequence: 3_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: 1201-?
        Exon_number: 10/10
    Interactor: WBInteraction000543331
      WBInteraction000555218
  Genetics: Interpolated_map_position: II 3.13053
    Mapping_data: In_multi_point: 2795
        2796
  Description: Phenotype: WBPhenotype:0000052 Paper_evidence: WBPaper00001883
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Many progeny from mog-6; fem-3 mothers die as embryos or young larvae Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
          Mel if feminized by fem-3. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
            WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Maternal
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
          Genotype: fem-3(e1996) Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000385 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Remark: XX mog mutant adults produce two to five times the normal number of sperm Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000683 Paper_evidence: WBPaper00001883
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Germ cells that would normally become oocytes have been transformed into sperm instead Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
          ts Mog, at 25C fully penetrant Mog: hermaphrodite germline makes only sperm Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Complete: 100 percent Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
            at 25C, fully penetrant Mog Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: At 15 degrees sterile non-Mog. Mel if feminized by fem-3. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000900 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Remark: Germ lines have a variable phenotype at 15C. Some mutant germlines contain only sperm and others contain unusual gametes Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001360 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001694 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Remark: In most mog-2-mog-6 homozygotes grown at 25C, spermatogenesis begins at the normal time and continues without switching to oogenesis Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000416 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Remark: Animals produce refractile yolk droplets Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000695 Paper_evidence: WBPaper00001883
        Curator_confirmed: WBPerson2021
        Remark: Animals grown at 25C have a normal vulva Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001883
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00001883
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001883
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001883
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00001883
  Method: Deletion_allele