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WormBase Tree Display for Variation: WBVar00144524

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Name Class

WBVar00144524EvidencePaper_evidenceWBPaper00024442
NamePublic_namee2055
Other_nameCE27762:p.Gly565Glu
F55B12.3a.1:c.1700G>A
F55B12.3b.1:c.1694G>A
CE25007:p.Gly567Glu
HGVSgCHROMOSOME_V:g.13822314G>A
Sequence_detailsSMapS_parentSequenceF55B12
Flanking_sequencesTTTGTTCTACTTCTACGATGCTAGCGTGTGCAGTCGATCTCGTAACAACACCGAGGAGACCAAAGTTATCCTTCTCGACTTTGATG
Mapping_targetF55B12
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryCB
StatusLive
AffectsGeneWBGene00004767
TranscriptF55B12.3b.1 (12)
F55B12.3a.1 (12)
InteractorWBInteraction000052164
GeneticsInterpolated_map_positionV5.62166
Mapping_dataIn_multi_point3379
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00024442
WBPaper00001133
Curator_confirmedWBPerson712
WBPerson2021
RemarkThe penetrance of the egg-laying defect in e2055 heterozygotes is cold-sensitive (at 15 C and 20 C). See Table 7Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
PenetranceIncompleteAt 15 C and 20 C, 56 percent of e2055 heterozygotes are EglPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
CompleteFully penetrant at 15C or 20C but only partially penetrant at 25C.Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson712
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature_sensitiveCold_sensitive15 | 20Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson712
Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature15, 20, 25Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Genotypee2055/+Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0000683Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
RemarkCauses significant masculinization of hermaphrodites.Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
Semi_dominantPaper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
Variation_effectNeomorph_gain_of_functionPaper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
WBPhenotype:0001220Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
RemarkHSNs undergo embryonic apoptosis in hermaphroditesPaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Temperature_sensitiveCold_sensitivePaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0001275Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
RemarkCauses increased lin-12 signaling.Paper_evidenceWBPaper00024442
Curator_confirmedWBPerson48
ReferenceWBPaper00001105
WBPaper00001133
WBPaper00024442
WBPaper00010313
MethodSubstitution_allele