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WormBase Tree Display for Variation: WBVar00144281

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Name Class

WBVar00144281EvidencePaper_evidenceWBPaper00003948
NamePublic_namee1752
Other_nameY41D4B.13a.1:c.459G>A
CE28360:p.Trp153Ter
HGVSgCHROMOSOME_IV:g.1600197G>A
Sequence_detailsSMapS_parentSequenceY41D4B
Flanking_sequencestttttttccagcaaaaacgaaccaggattgtgggaggcgagaaacgcgttgggaaccact
Mapping_targetY41D4B
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004459
WBStrain00004482
WBStrain00027172
WBStrain00027173
WBStrain00027276
LaboratoryCB
StatusLive
Affects (3)
GeneticsInterpolated_map_positionIV-16.5924
Mapping_dataIn_2_point645
In_multi_point578
2437
DescriptionPhenotypeWBPhenotype:0000241Paper_evidenceWBPaper00003948
Curator_confirmedWBPerson712
WBPhenotype:0000243Paper_evidenceWBPaper00050421
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPerson2987
Remarkkiller cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); extensive maternal rescuePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
persistent corpses in the pharynx of L1 (Supplemental Table 1)Paper_evidenceWBPaper00050421
Curator_confirmedWBPerson2987
Variation_effectPredicted_null_via_sequencePaper_evidenceWBPaper00050421
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0003681PATO:0000460Paper_evidenceWBPaper00050421
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00050421
Curator_confirmedWBPerson2987
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000301Paper_evidenceWBPaper00003948
Curator_confirmedWBPerson712
RemarkDistal tip cells did not follow a typical path, resulting in gonad arms that exhibited inappropriate turns, twists, or positions with in the body cavity.Paper_evidenceWBPaper00003948
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00003948
Curator_confirmedWBPerson712
WBPhenotype:0000885Paper_evidenceWBPaper00001438
WBPaper00038317
WBPaper00050047
Curator_confirmedWBPerson2021
WBPerson712
WBPerson7492
RemarkFailure to engulf cell corpsesPaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
Persistent cell corpses accumulate.Paper_evidenceWBPaper00038317
Curator_confirmedWBPerson712
Midbodies not phagocytosedPaper_evidenceWBPaper00050047
Curator_confirmedWBPerson7492
PenetranceCompletePaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005739PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBbt:0003681PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBbt:0005741PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBbt:0005829PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBbt:0003666PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBls:0000037PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
Maternal
WBPhenotype:0001172Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkprogrammed cell deaths abnormal, dying cells arrest at highly refractile stage; extensive maternal rescuePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observed (6)
Reference (12)
RemarkThis substitution allele is coupled with a downstream mutation [G192 to E]Paper_evidenceWBPaper00003948
MethodSubstitution_allele