WormBase Tree Display for Variation: WBVar00143705
expand all nodes | collapse all nodes | view schema
WBVar00143705 | Evidence | Paper_evidence | WBPaper00004275 | ||||
---|---|---|---|---|---|---|---|
Name | Public_name | e1048 | |||||
Other_name | e1048sd | ||||||
JC8.10a.1:c.2143G>A | |||||||
CE28239:p.Gly715Arg | |||||||
CE29050:p.Gly721Arg | |||||||
JC8.10b.1:c.2161G>A | |||||||
HGVSg | CHROMOSOME_IV:g.13265339C>T | ||||||
Sequence_details | SMap | S_parent | Sequence | JC8 | |||
Flanking_sequences | attgactcgcatgacgtcatattttggttg | gagatttcaactatcgaattaatttgtcgg | |||||
Mapping_target | JC8 | ||||||
Type_of_mutation | Substitution | g | a | ||||
SeqStatus | Sequenced | ||||||
Variation_type | Allele | ||||||
Origin | Species | Caenorhabditis elegans | |||||
Laboratory | CB | ||||||
Status | Live | ||||||
Affects | Gene | WBGene00006763 | |||||
Transcript | JC8.10b.1 (12) | ||||||
JC8.10a.1 (12) | |||||||
Genetics | Interpolated_map_position | IV | 8.5125 | ||||
Description | Phenotype | WBPhenotype:0000017 | Paper_evidence | WBPaper00004275 | |||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants are strongly resistant to inhibitors of acetylcholinesterase, indicative of a decrease in acetylcholine release. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000210 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants have reduced numbers of enteric muscle contractions, indicative of GABAergic function. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000229 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals are small. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000455 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals move backwards with a jerky motion. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000565 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; frequently coil. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000644 | Paper_evidence | WBPaper00001303 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Animals remain completely paralyzed at all stages of its life. | Paper_evidence | WBPaper00001303 | ||||
Curator_confirmed | WBPerson712 | ||||||
Variation_effect | Null | Paper_evidence | WBPaper00001303 | ||||
Curator_confirmed | WBPerson712 | ||||||
Reference | WBPaper00004275 | ||||||
WBPaper00013791 | |||||||
WBPaper00001303 | |||||||
Method | Substitution_allele |