WormBase Tree Display for Variation: WBVar00143216
expand all nodes | collapse all nodes | view schema
WBVar00143216 | Evidence | Paper_evidence | WBPaper00004275 | ||||
---|---|---|---|---|---|---|---|
Name | Public_name | e446 | |||||
Other_name | CE29050:p.Glu623Ter | ||||||
JC8.10b.1:c.1867G>T | |||||||
CE28239:p.Glu617Ter | |||||||
JC8.10a.1:c.1849G>T | |||||||
HGVSg | CHROMOSOME_IV:g.13265633C>A | ||||||
Sequence_details | SMap | S_parent | Sequence | Y67H2A | |||
Flanking_sequences | gaaaaagctccatttgtgctcattggctcc | agcagctcgtcggtgtttgtctattcctct | |||||
Mapping_target | Y67H2A | ||||||
Type_of_mutation | Substitution | g | t | Paper_evidence | WBPaper00004275 | ||
SeqStatus | Sequenced | ||||||
Variation_type | Allele | ||||||
Origin | Species | Caenorhabditis elegans | |||||
Laboratory | CB | ||||||
Status | Live | ||||||
Affects | Gene | WBGene00006763 | |||||
Transcript (2) | |||||||
Genetics | Interpolated_map_position | IV | 8.51276 | ||||
Description | Phenotype | WBPhenotype:0000017 | Paper_evidence | WBPaper00004275 | |||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants are strongly resistant to inhibitors of acetylcholinesterase, indicative of a decrease in acetylcholine release. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000210 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants have reduced numbers of enteric muscle contractions, indicative of GABAergic function. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000229 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals are small. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000455 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals move backwards with a jerky motion. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000565 | Paper_evidence | WBPaper00004275 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Strong allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; frequently coil. | Paper_evidence | WBPaper00004275 | ||||
Curator_confirmed | WBPerson712 | ||||||
Reference | WBPaper00004275 | ||||||
WBPaper00013791 | |||||||
Remark | In addition to the E(623)* described, e446 also has an R(709)T mutation. | Paper_evidence | WBPaper00004275 | ||||
Method | Substitution_allele |