WormBase Tree Display for Variation: WBVar00095135

WBVar00095135 Name: Public_name: p1152
    Other_name: ZC416.8b.1:c.1751C>T
      CE17308:p.Pro584Leu
    HGVSg: CHROMOSOME_IV:g.3614187G>A
  Sequence_details: SMap: S_parent: Sequence: ZC416
    Flanking_sequences: GTGCAGTGGTCCGCGATGGCTATGGATGCC GTACAATATTCAACCGGATCGAGTGATTTT
    Mapping_target: ZC416
    Type_of_mutation: Substitution: C T Person_evidence: WBPerson13860
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00027069
      WBStrain00030801
    Laboratory: PR
    Status: Live
  Affects: Gene: WBGene00000481
    Transcript: ZC416.8b.1 (12)
    Interactor: WBInteraction000518557
  Genetics: Interpolated_map_position: IV -3.11911
    Mapping_data: In_2_point: 523
      In_multi_point: 52
        275
        455
        458
        462
        466
        596
        923
        924
  Description: Phenotype: WBPhenotype:0000017 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Ric (resistant to aldicarb, trichlorfon) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
            WBMol:00002865 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000019 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow pumping Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000031 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow-growing Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000039 Paper_evidence: WBPaper00040570
        Curator_confirmed: WBPerson8126
        Remark: Fig. 3 reduction in lifespan upon reserpine treatment, opposite to what is seen in wild type animals Paper_evidence: WBPaper00040570
            Curator_confirmed: WBPerson8126
        Affected_by: Molecule: WBMol:00002955 Paper_evidence: WBPaper00040570
              Curator_confirmed: WBPerson8126
      WBPhenotype:0000124 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: 99% reduced choline acetyltransferase Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000246 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0000384 Paper_evidence: WBPaper00040041
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit AVM ventral axon guidance defects. DD and VD neurons migrate normally in these mutants and are unaffected by exogenous acetylcholine. Paper_evidence: WBPaper00040041
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004765 Paper_evidence: WBPaper00040041
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003832 PATO:0000460 Paper_evidence: WBPaper00040041
                Curator_confirmed: WBPerson712
      WBPhenotype:0000565 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: uncoordinated (coiler) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000631 Paper_evidence: WBPaper00036766
        Curator_confirmed: WBPerson712
        Remark: cha-1 reduction-of-function allele did not significantly alter fluoxetine sensitivity. Paper_evidence: WBPaper00036766
            Curator_confirmed: WBPerson712
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00036766
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005058 Paper_evidence: WBPaper00036766
              Curator_confirmed: WBPerson712
  Reference: WBPaper00016510
    WBPaper00040041
    WBPaper00040570
    WBPaper00016519
    WBPaper00029012
    WBPaper00022015
    WBPaper00016184
    WBPaper00017502
    WBPaper00036766
  Remark: Sequenced the above strain and found the above mutation, corresponding to the uncharacterised p1152 allele. Person_evidence: WBPerson13860
  Method: Substitution_allele