WormBase Tree Display for Variation: WBVar00095119

WBVar00095119 Evidence: Paper_evidence: WBPaper00002584
  Name: Public_name: p691
    Other_name: F36F2.5.1:c.1282C>T
      CE17780:p.Pro428Ser
    HGVSg: CHROMOSOME_I:g.9023823C>T
  Sequence_details: SMap: S_parent: Sequence: C31H5
    Flanking_sequences: gtggccacatctactggaaataacccagca caactaatgttatcgagtgagtgactagtt
    Mapping_target: C31H5
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00002584
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00030788
    Laboratory: PR
    Status: Live
  Affects: Gene: WBGene00006525
    Transcript: F36F2.5.1 VEP_consequence: missense_variant
        VEP_impact: MODERATE
        HGVSc: F36F2.5.1:c.1282C>T
        HGVSp: CE17780:p.Pro428Ser
        cDNA_position: 1282
        CDS_position: 1282
        Protein_position: 428
        Exon_number: 8/15
        Codon_change: Cca/Tca
        Amino_acid_change: P/S
    Interactor: WBInteraction000501490
      WBInteraction000501959
      WBInteraction000501963
  Genetics: Interpolated_map_position: I 3.40676
  Description: Phenotype (14)
    Phenotype_not_observed: WBPhenotype:0001285 Paper_evidence: WBPaper00045598
        Curator_confirmed: WBPerson712
        Remark: Mutants show a significant reduction in pumping following exposure to 10% CO2, similar to the reduction observed in wild-type (N2) animals Paper_evidence: WBPaper00045598
            Curator_confirmed: WBPerson712
          When exposed to 10% CO2, mutants stopped pumping, similar to wild-type animals. Paper_evidence: WBPaper00045598
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003023 Paper_evidence: WBPaper00045598
              Curator_confirmed: WBPerson712
      WBPhenotype:0001448 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Remark: Benzaldehyde avoidance of tax-2 mutants is indistinguishable from that of wild-type Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 2-3 ul of benzaldehyde Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001736 Paper_evidence: WBPaper00031959
        Curator_confirmed: WBPerson712
        Remark: Animals showed no defect in acetate chemotaxis in water soluble assays when compared to che-1(p679) positive control animals (data not shown). Paper_evidence: WBPaper00031959
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005057 Paper_evidence: WBPaper00031959
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: For the water soluble chemotaxis assay, radial gradients of NaAc were established by diffusion in the agar. Paper_evidence: WBPaper00031959
              Curator_confirmed: WBPerson712
      WBPhenotype:0001897 Paper_evidence: WBPaper00032087
        Curator_confirmed: WBPerson2021
        Remark: Loss-of-function mutations in the TAX-2 CNG channels do not affect the overall locomotion response to short wavelength light Paper_evidence: WBPaper00032087
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032087
            Curator_confirmed: WBPerson2021
  Reference (19)
  Method: Substitution_allele