WormBase Tree Display for Variation: WBVar00095036

WBVar00095036 Evidence: Paper_evidence: WBPaper00005098
  Name: Public_name: oy38
    Other_name: F58H12.1.1:c.1314-275_1565del
    HGVSg: CHROMOSOME_X:g.2846623_2847149del
  Sequence_details: SMap: S_parent: Sequence: F58H12
    Flanking_sequences: tgttgtgtcaaatcgaagttagttggcaga aaacaaactattttatcaaagttaatttg
    Mapping_target: F58H12
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031130
      WBStrain00047961
      WBStrain00047962
    Laboratory: PY
    Status: Live
  Affects: Gene: WBGene00002210
    Transcript: F58H12.1.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F58H12.1.1:c.1314-275_1565del
        cDNA_position: ?-1616
        CDS_position: ?-1565
        Protein_position: ?-522
        Intron_number: 12/17
        Exon_number: 13/18
    Interactor: WBInteraction000569803
  Genetics: Interpolated_map_position: X -12.7094
  Description: Phenotype: WBPhenotype:0000061 Paper_evidence: WBPaper00060059
        Curator_confirmed: WBPerson2987
        Remark: "As previously reported (Lanjuin and Sengupta, 2002), kin-29(oy38) mutants are long-lived." Figure 1A, 1B Paper_evidence: WBPaper00060059
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Strain: WBStrain00047961 Paper_evidence: WBPaper00060059
              Curator_confirmed: WBPerson2987
          Control_strain: WBStrain00000001 Paper_evidence: WBPaper00060059
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000154 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: Mutants show a reduction in brood size Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000229 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: kin-29 mutant animals are small. The Sma body size of kin-29 is due to a delay in development in later larval stages Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001524 Paper_evidence: WBPaper00051005
        Curator_confirmed: WBPerson38423
        Remark: "a null mutation of kin-29, the C. elegans orthologue of Sik3, reduced the fraction of quiescence during L4-adult lethargus, a sleep-like state in C. elegans (Fig. 3e)"; In figure 3e legend, "kin-29(oy38); PH20::kin-29 worms (n=9), in which wild type kin-29 was expressed in neuronal cells, restored normal quiescence during lethargus." Paper_evidence: WBPaper00051005
            Curator_confirmed: WBPerson38423
        Variation_effect: Null: Paper_evidence: WBPaper00051005
            Curator_confirmed: WBPerson38423
        EQ_annotations: Life_stage: WBls:0000039 PATO:0000460 Paper_evidence: WBPaper00051005
                Curator_confirmed: WBPerson38423
        Phenotype_assay: Strain: WBStrain00031130 Paper_evidence: WBPaper00051005
              Curator_confirmed: WBPerson38423
          Control_strain: WBStrain00000001 Paper_evidence: WBPaper00051005
              Curator_confirmed: WBPerson38423
      WBPhenotype:0002432 Paper_evidence: WBPaper00059622
        Curator_confirmed: WBPerson712
        Remark: KIN-29 AID transgenic animals cultivated on auxin throughout development mimicked the kin-29(oy38) null mutant SIS Paper_evidence: WBPaper00059622
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0004030 Paper_evidence: WBPaper00061691
        Curator_confirmed: WBPerson712
        Remark: "...kin-2 mutant males as well those mutant for kin-29, F47F2.1 or pde-4, which all affect cAMP-dependent signaling, were not obviously defective in their response to hermaphrodites." Paper_evidence: WBPaper00061691
            Curator_confirmed: WBPerson712
  Reference: WBPaper00025090
    WBPaper00051005
    WBPaper00059622
    WBPaper00060059
    WBPaper00061691
    WBPaper00064927
  Method: Deletion_allele