WormBase Tree Display for Variation: WBVar00094687

WBVar00094687 Evidence: Paper_evidence: WBPaper00005096
  Name: Public_name: or180
    Other_name: CE26888:p.Ser502Phe
      F10C5.1.1:c.1505C>T
    HGVSg: CHROMOSOME_III:g.481323C>T
  Sequence_details: SMap: S_parent: Sequence: F10C5
    Flanking_sequences: aggaagctcaaaaatgcaaaccccatgatt tcggcttctcgtggctctcggtgatatata
    Mapping_target: F10C5
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00006407
    Laboratory: EU
    Status: Live
  Affects: Gene: WBGene00003134
    Transcript: F10C5.1.1 VEP_consequence: missense_variant
        VEP_impact: MODERATE
        HGVSc: F10C5.1.1:c.1505C>T
        HGVSp: CE26888:p.Ser502Phe
        cDNA_position: 1514
        CDS_position: 1505
        Protein_position: 502
        Exon_number: 8/10
        Codon_change: tCt/tTt
        Amino_acid_change: S/F
    Interactor: WBInteraction000052178
      WBInteraction000500085
      WBInteraction000500086
      WBInteraction000500089
      WBInteraction000500092
      WBInteraction000518318
  Genetics: Interpolated_map_position: III -26.8385
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00032281
          WBPaper00037671
        Curator_confirmed: WBPerson712
        Remark: 10/342 eggs hatched. Paper_evidence: WBPaper00032281
            Curator_confirmed: WBPerson712
          Suppressed by such-1(av9). Paper_evidence: WBPaper00037671
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 24 Paper_evidence: WBPaper00032281
                WBPaper00037671
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Three L4 hermaphrodites fed with HT115 bacteria expressing pUC19 as a control plasmid, were shifted to 24 C for 36 h, and then the total number of eggs laid and hatching were counted. Paper_evidence: WBPaper00032281
              Curator_confirmed: WBPerson712
      WBPhenotype:0000313 Paper_evidence: WBPaper00032281
        Curator_confirmed: WBPerson712
        Remark: Embryos arrested at metaphase of meiosis I; animals laid one-cell embryos (n=30). Paper_evidence: WBPaper00032281
            Curator_confirmed: WBPerson712
        Penetrance: High: Paper_evidence: WBPaper00032281
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 24 Paper_evidence: WBPaper00032281
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Thirty L4 hermaphrodites fed with HT115 bacteria with control vector pUC10 were shifted to 24C for 24 h, fixed with methanol and acetone, and then stained with 100 ng/ml DAPI. The numbers of worms that lay only embryos in meiotic division (one cell) and those that lay embryos that had entered mitosis (more than one cell) are shown. Paper_evidence: WBPaper00032281
              Curator_confirmed: WBPerson712
      WBPhenotype:0001216 Paper_evidence: WBPaper00004484
        Curator_confirmed: WBPerson205
  Reference: WBPaper00018375
    WBPaper00037671
    WBPaper00004484
    WBPaper00032281
    WBPaper00025832
    WBPaper00010392
  Method: Substitution_allele